Phenotypes associated with this allele

• Allele Symbol: Tg(H2-K1-HLA-A*)28Mpla
• Allele Name: transgene insertion 28, Marika Pla
• Allele ID: MGI:5428682
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(H2-K1-HLA-A*)28Mpla/0	B10.Cg-Tg(H2-K1-HLA-A*)28Mpla	MGI:5428686

Genotype
MGI:5428686

tg1

• Allelic Composition: Tg(H2-K1-HLA-A*)28Mpla/0
• Genetic Background: B10.Cg-Tg(H2-K1-HLA-A*)28Mpla

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

eye inflammation ( J:67871 )

• retinal vasculitis and perivasculitis in some mice aged 12 months or more

• inflammation is largely confined to the posterior segment of the eye

• the vitreous and the optic disk are infiltrated by inflammatory cells and this is frequently associated with inflammation in the arachnoid of the optic nerve and in the choroid

choroid inflammation ( J:67871 )

abnormal eye pigmentation ( J:67871 )

• cells containing pigment are present in the subretinal space forming clusters located under retinal folds

abnormal retina morphology ( J:67871 )

• some mice aged 12 months or more develop spontaneous, typically bilateral retinopathy

abnormal retina pigment epithelium morphology ( J:67871 )

• thickened

retina detachment ( J:67871 )

• local detachments are frequently seen in mice aged 12 months or more

retina fold ( J:67871 )

immune system

eye inflammation ( J:67871 )

• retinal vasculitis and perivasculitis in some mice aged 12 months or more

• inflammation is largely confined to the posterior segment of the eye

• the vitreous and the optic disk are infiltrated by inflammatory cells and this is frequently associated with inflammation in the arachnoid of the optic nerve and in the choroid

choroid inflammation ( J:67871 )

pigmentation

abnormal eye pigmentation ( J:67871 )

• cells containing pigment are present in the subretinal space forming clusters located under retinal folds

abnormal retina pigment epithelium morphology ( J:67871 )

• thickened

cardiovascular system

vascular inflammation ( J:67871 )

• retinal vasculitis and perivasculitis in some mice aged 12 months or more

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
birdshot chorioretinopathy		DOID:0111079	OMIM:605808	J:67871