All Phenotypes Hprt1<tm1(Nphs1-CMIP)Dsah> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hprt1^{tm1(Nphs1-CMIP)Dsah}
targeted mutation 1, Djillali Sahali
MGI:5428689

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hprt1^{tm1(Nphs1-CMIP)Dsah}/Hprt1⁺	B6.Cg-Hprt1^{tm1(Nphs1-CMIP)Dsah}	MGI:5428692

Allelic Composition	Hprt1^{tm1(Nphs1-CMIP)Dsah}/Hprt1⁺
Genetic Background	B6.Cg-Hprt1^{tm1(Nphs1-CMIP)Dsah}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm1(Nphs1-CMIP)Dsah} mutation (0 available); any Hprt1 mutation (1279 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

increased mesangial cell number ( J:185411 )

• at 6 months in some glomeruli

increased urine protein level ( J:185411 )

albuminuria ( J:185411 )

abnormal podocyte morphology ( J:185411 )

• flattened and widened

podocyte foot process effacement ( J:185411 )

abnormal podocyte slit diaphragm morphology ( J:185411 )

• narrow in most glomeruli

absent podocyte slit diaphragm ( J:185411 )

• in some areas

expanded mesangial matrix ( J:185411 )

• at 1 year in some glomeruli

glomerulosclerosis ( J:185411 )

• some focal and segmental glomerulosclerosis lesions at 1 year in some glomeruli

homeostasis/metabolism

increased urine protein level ( J:185411 )

albuminuria ( J:185411 )

cellular

increased mesangial cell number ( J:185411 )

• at 6 months in some glomeruli

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
nephrotic syndrome		DOID:1184		J:185411

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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