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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Arap3tm1.1Sve
targeted mutation 1.1, Sonja Vermeren
MGI:5428753
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Arap3tm1.1Sve/Arap3tm1.2Sve
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL MGI:5428759
cn2
 		Arap3tm1.1Sve/Arap3tm1.2Sve
Tg(Tek-cre)1Ywa/0 		involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL MGI:5428758


Genotype
MGI:5428759
cn1
Allelic
Composition		 Arap3tm1.1Sve/Arap3tm1.2Sve
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arap3tm1.1Sve mutation (0 available); any Arap3 mutation (61 available)
Arap3tm1.2Sve mutation (0 available); any Arap3 mutation (61 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:185401 )
• die around E11
• identical to mice homozygous for Arap3tm1.2Sve

embryo
abnormal placenta vasculature ( J:185401 )
• identical to mice homozygous for Arap3tm1.2Sve
abnormal placenta labyrinth morphology ( J:185401 )
• defect in labyrinth formation

cardiovascular system
abnormal placenta vasculature ( J:185401 )
• identical to mice homozygous for Arap3tm1.2Sve

growth/size/body
decreased embryo size ( J:185401 )

integument




Genotype
MGI:5428758
cn2
Allelic
Composition		 Arap3tm1.1Sve/Arap3tm1.2Sve
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arap3tm1.1Sve mutation (0 available); any Arap3 mutation (61 available)
Arap3tm1.2Sve mutation (0 available); any Arap3 mutation (61 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:185401 )
• die around E11
• identical to mice homozygous for Arap3tm1.2Sve

cardiovascular system
abnormal brain vasculature morphology ( J:185401 )
• the capillary network is replaced with a large accumulation of endothelial cells
abnormal placenta vasculature ( J:185401 )
• identical to mice homozygous for Arap3tm1.2Sve
abnormal developmental vascular remodeling ( J:185401 )
• defect in vascular maturation and remodeling, especially apparent in the midbrain
abnormal vitelline vasculature morphology ( J:185401 )
• unevenly sized vessel lumens, some of which are large, giving an impression of accumulations of endothelial cells

embryo
abnormal placenta vasculature ( J:185401 )
• identical to mice homozygous for Arap3tm1.2Sve
abnormal vitelline vasculature morphology ( J:185401 )
• unevenly sized vessel lumens, some of which are large, giving an impression of accumulations of endothelial cells
abnormal placenta labyrinth morphology ( J:185401 )
• defect in labyrinth formation
decreased placental labyrinth size ( J:185401 )
• identical to mice homozygous for Arap3tm1.2Sve
excessive folding of visceral yolk sac ( J:185401 )
• wrinkled yolk sac at E10.5
abnormal vitelline vascular remodeling ( J:185401 )
• the primary vascular plexus fails to remodel

growth/size/body
decreased embryo size ( J:185401 )
• at E10.5

integument
pallor ( J:185401 )
• at E10.5

nervous system
abnormal brain vasculature morphology ( J:185401 )
• the capillary network is replaced with a large accumulation of endothelial cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory