All Phenotypes Arap3<tm1.2Sve> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arap3^tm1.2Sve/Arap3^tm1.2Sve	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL	MGI:5428756
ht2	Arap3^tm1.2Sve/Arap3⁺	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL	MGI:5428757
cn3	Arap3^tm1.1Sve/Arap3^tm1.2Sve Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL	MGI:5428759
cn4	Arap3^tm1.1Sve/Arap3^tm1.2Sve Tg(Tek-cre)1Ywa/0	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL	MGI:5428758

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:185401 )

• die around E11

embryo

abnormal placenta vasculature ( J:185401 )

• lack of invaginating blood vessels into the trophoblast layer and absence of branching morphogenesis of the vessels

• networks generated by the allantois are smaller and less complex

abnormal vitelline vasculature morphology ( J:185401 )

• unevenly sized vessel lumens, some of which are large, giving an impression of accumulations of endothelial cells

• yolk sacs display large open spaces which are lined by endothelial cells

embryonic growth arrest ( J:185401 )

decreased embryo size ( J:185401 )

• at E10.5

abnormal placenta labyrinth morphology ( J:185401 )

• defect in labyrinth formation

decreased placental labyrinth size ( J:185401 )

• defect in labyrinth formation

excessive folding of visceral yolk sac ( J:185401 )

• wrinkled yolk sac at E10.5

pale yolk sac ( J:185401 )

• blood cells appear to accumulate in a few places

• however, no defect in embryonic hematopoiesis is detected

abnormal vitelline vascular remodeling ( J:185401 )

• the primary vascular plexus fails to remodel

cardiovascular system

abnormal brain vasculature morphology ( J:185401 )

• the capillary network is replaced with a large accumulation of endothelial cells

• no capillary sprouting from the perineural plexus toward the midline is observed in hindbrains

abnormal placenta vasculature ( J:185401 )

• lack of invaginating blood vessels into the trophoblast layer and absence of branching morphogenesis of the vessels

• networks generated by the allantois are smaller and less complex

abnormal angiogenesis ( J:185401 )

abnormal developmental vascular remodeling ( J:185401 )

• defect in vascular maturation and remodeling, especially apparent in the midbrain

abnormal vascular branching morphogenesis ( J:185401 )

• vascular networks formed in cultures of para-aortic splanchnopleural region explants

• from E8.5 embryos are not as complex with fewer but thicker branches and contain characteristic endothelial cell accumulations

• decreased branching indices in networks formed by allantois explants

• no capillary sprouting from the perineural plexus toward the midline is observed in hindbrains

• at E10.5 in the region below the otic vesicle no new sprouts are detected and the neck region contains fewer, thicker vessels

abnormal vitelline vasculature morphology ( J:185401 )

• unevenly sized vessel lumens, some of which are large, giving an impression of accumulations of endothelial cells

• yolk sacs display large open spaces which are lined by endothelial cells

integument

pallor ( J:185401 )

• at E10.5

nervous system

abnormal brain vasculature morphology ( J:185401 )

• the capillary network is replaced with a large accumulation of endothelial cells

• no capillary sprouting from the perineural plexus toward the midline is observed in hindbrains

growth/size/body

decreased embryo size ( J:185401 )

• at E10.5

Allelic Composition	Arap3^tm1.2Sve/Arap3⁺
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arap3^tm1.2Sve mutation (0 available); any Arap3 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal brain vasculature morphology ( J:185401 )

• the complexity of the network formed is reduced in E10.5 hindbrains with shorter vessels, incompletely formed interconnections and fewer branching points

• however, by E11.5 these differences are no longer apparent

abnormal angiogenesis ( J:185401 )

• slight delay in vascularization seen at E10.5 but no longer detected at E11.5

nervous system

abnormal brain vasculature morphology ( J:185401 )

• the complexity of the network formed is reduced in E10.5 hindbrains with shorter vessels, incompletely formed interconnections and fewer branching points

• however, by E11.5 these differences are no longer apparent

Allelic Composition	Arap3^tm1.1Sve/Arap3^tm1.2Sve Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arap3^tm1.1Sve mutation (0 available); any Arap3 mutation (61 available)
Arap3^tm1.2Sve mutation (0 available); any Arap3 mutation (61 available)
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:185401 )

• die around E11

• identical to mice homozygous for Arap3^tm1.2Sve

embryo

abnormal placenta vasculature ( J:185401 )

• identical to mice homozygous for Arap3^tm1.2Sve

embryonic growth arrest ( J:185401 )

decreased embryo size ( J:185401 )

abnormal placenta labyrinth morphology ( J:185401 )

• defect in labyrinth formation

decreased placental labyrinth size ( J:185401 )

excessive folding of visceral yolk sac ( J:185401 )

• wrinkled yolk sac

pale yolk sac ( J:185401 )

cardiovascular system

abnormal placenta vasculature ( J:185401 )

• identical to mice homozygous for Arap3^tm1.2Sve

growth/size/body

decreased embryo size ( J:185401 )

integument

pallor ( J:185401 )

Allelic Composition	Arap3^tm1.1Sve/Arap3^tm1.2Sve Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:185401 )

• die around E11

• identical to mice homozygous for Arap3^tm1.2Sve

cardiovascular system

abnormal brain vasculature morphology ( J:185401 )

• the capillary network is replaced with a large accumulation of endothelial cells

abnormal placenta vasculature ( J:185401 )

• identical to mice homozygous for Arap3^tm1.2Sve

abnormal developmental vascular remodeling ( J:185401 )

• defect in vascular maturation and remodeling, especially apparent in the midbrain

abnormal vitelline vasculature morphology ( J:185401 )

• unevenly sized vessel lumens, some of which are large, giving an impression of accumulations of endothelial cells

embryo

abnormal placenta vasculature ( J:185401 )

• identical to mice homozygous for Arap3^tm1.2Sve

abnormal vitelline vasculature morphology ( J:185401 )

• unevenly sized vessel lumens, some of which are large, giving an impression of accumulations of endothelial cells

embryonic growth arrest ( J:185401 )

decreased embryo size ( J:185401 )

• at E10.5

abnormal placenta labyrinth morphology ( J:185401 )

• defect in labyrinth formation

decreased placental labyrinth size ( J:185401 )

• identical to mice homozygous for Arap3^tm1.2Sve

excessive folding of visceral yolk sac ( J:185401 )

• wrinkled yolk sac at E10.5

pale yolk sac ( J:185401 )

abnormal vitelline vascular remodeling ( J:185401 )

• the primary vascular plexus fails to remodel

growth/size/body

decreased embryo size ( J:185401 )

• at E10.5

integument

pallor ( J:185401 )

• at E10.5

nervous system

abnormal brain vasculature morphology ( J:185401 )

• the capillary network is replaced with a large accumulation of endothelial cells

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