Phenotypes associated with this allele

• Allele Symbol: Arap3^tm2.1Sve
• Allele Name: targeted mutation 2.1, Sonja Vermeren
• Allele ID: MGI:5428755
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arap3^tm2.1Sve/Arap3^tm2.1Sve	involves: 129P2/OlaHsd	MGI:5428760

Genotype
MGI:5428760

hm1

• Allelic Composition: Arap3^tm2.1Sve/Arap3^tm2.1Sve
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:185401 )

• die around E11

• phenocopy mice homozygous for Arap3^tm1.2Sve

cardiovascular system

abnormal brain vasculature morphology ( J:185401 )

• midbrains are characterized by an endothelial cell?lined sinus at E10.5

• absence of sprouting towards the midline in the hindbrain at E10.5

abnormal vascular branching morphogenesis ( J:185401 )

• absence of sprouting towards the midline in the hindbrain at E10.5

• in the embryonic neck region there are fewer vessels with larger diameters and sprouting angiogenesis is absent

• cultures of explants from para-aortic splanchnopleural regions form characteristic endothelial cell accumulations

• allantois explants are characterized by reduced complexity, less sprouting, and smaller branching indices

abnormal vitelline vasculature morphology ( J:185401 )

embryo

abnormal vitelline vasculature morphology ( J:185401 )

decreased embryo size ( J:185401 )

excessive folding of visceral yolk sac ( J:185401 )

growth/size/body

decreased embryo size ( J:185401 )

integument

pallor ( J:185401 )

nervous system

abnormal brain vasculature morphology ( J:185401 )

• midbrains are characterized by an endothelial cell?lined sinus at E10.5

• absence of sprouting towards the midline in the hindbrain at E10.5