Analysis Tools
mortality/aging
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• males become moribound on average at around the 4th month of life, while females survive to around 10 months of age; reason for morbidity is unclear
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renal/urinary system
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• mutants develop polycystic kidney disease with complete penetrance; disease is more severe in males than females
• 2 month old kidneys are pale and enlarged 5-fold, with a bosselated cortical surface; entire kidney is occupied by predominant cysts intermingled with tubular clusters
• however, mutants do not develop liver or pancreatic cysts or renal failure
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reproductive system
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• mutants exhibit lesions in epididymis
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• some mutants exhibit enlarged epididymis; the ductus epididymis is distended and surrounded by a thick connective interstitium infiltrated with inflammatory cells
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hematopoietic system
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• mutants exhibit lesions in the thymus
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• some mutants exhibit enlarged thymus
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immune system
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• mutants exhibit lesions in the thymus
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• some mutants exhibit enlarged thymus
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endocrine/exocrine glands
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• mutants exhibit lesions in the thymus
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• some mutants exhibit enlarged thymus
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growth/size/body
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• mutants develop polycystic kidney disease with complete penetrance; disease is more severe in males than females
• 2 month old kidneys are pale and enlarged 5-fold, with a bosselated cortical surface; entire kidney is occupied by predominant cysts intermingled with tubular clusters
• however, mutants do not develop liver or pancreatic cysts or renal failure
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| cystic kidney disease | DOID:2975 | J:44803 | ||
