Analysis Tools
behavior/neurological
| N |
• in a tone-cued fear conditioning test, mice do not show any differences in response compared to controls; this test is hippocampus-independent unlike other mutant phenotypes which are hippocampus-dependent, suggesting a defect in hippocampus function in these mutant mice
• AMPA receptor-mediated excitatory postsynaptic potentials in the CA1 region in response to various stimulus intensities are indistinguishable between mutants and controls
• paired-pulse facilitation observed in slices from homozygous mice does not significantly differ from that of wild-type mice at any interstimulus interval examined
• long-term synaptic plasticity analysis shows that a single high-frequency stimulus train (100 Hz/s) produces long-term potentiation in mutant slices that is indistinguishable from that of controls
|
|
• after an an electric foot shock conditioning stimulus, homozygous mice show normal freezing behavior during a 1-day retention period, but the freezing time is significantly reduced 4 days after the training
|
|
• in a hidden-platform Morris water maze test, both homozygotes and mice improve their performance during 5 days of training at 4 trials/day, and there are no significant difference between the two genotypes was observed for the time spent in the target quadrant one day after training
• however, mice spend less time in the target quadrant than that of controls 4 days after the training
|
