Phenotypes associated with this allele

• Allele Symbol: Tg(Pklr-Myc)73Ak
• Allele Name: transgene insertion 73, Axel Kahn
• Allele ID: MGI:5428913
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Lect2^tm1Ymg/Lect2^tm1Ymg Tg(Pklr-Myc)73Ak/0	B6.Cg-Lect2^tm1Ymg Tg(Pklr-Myc)73Ak	MGI:5430590
cx2	Tcra-J^tm1Tgi/Tcra-J^tm1Tgi Tg(Pklr-Myc)73Ak/0	B6.Cg-Tcra-J^tm1Tgi Tg(Pklr-Myc)73Ak	MGI:5430591
tg3	Tg(Pklr-Myc)73Ak/0	B6.Cg-Tg(Pklr-Myc)73Ak	MGI:5430592
tg4	Tg(Pklr-Myc)73Ak/0	involves: C57BL/6 * DBA	MGI:5428914

Genotype
MGI:5430590

cx1

• Allelic Composition: Lect2^tm1Ymg/Lect2^tm1Ymg; Tg(Pklr-Myc)73Ak/0
• Genetic Background: B6.Cg-Lect2^tm1Ymg Tg(Pklr-Myc)73Ak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased malignant tumor incidence ( J:184496 )

• tumors have higher grades of malignancy and are less differentiated than those of single Tg(Pklr-Myc)73Ak mice

increased hepatocellular carcinoma incidence ( J:184496 )

• mutants develop hepatocellular carcinoma

• the number and size of tumor nodules in double mutants is greater than in single Tg(Pklr-Myc)73Ak mice

• some tumors in double mutants exhibit a very poorly differentiated phenotype (fetal-like phenotype) that is never seen in tumors of single Tg(Pklr-Myc)73Ak mice

• tumors have higher mitotic indices compared with tumors from single Tg(Pklr-Myc)73Ak mice

liver/biliary system

increased hepatocellular carcinoma incidence ( J:184496 )

• mutants develop hepatocellular carcinoma

• the number and size of tumor nodules in double mutants is greater than in single Tg(Pklr-Myc)73Ak mice

• some tumors in double mutants exhibit a very poorly differentiated phenotype (fetal-like phenotype) that is never seen in tumors of single Tg(Pklr-Myc)73Ak mice

• tumors have higher mitotic indices compared with tumors from single Tg(Pklr-Myc)73Ak mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:184496

Genotype
MGI:5430591

cx2

• Allelic Composition: Tcra-J^tm1Tgi/Tcra-J^tm1Tgi; Tg(Pklr-Myc)73Ak/0
• Genetic Background: B6.Cg-Tcra-J^tm1Tgi Tg(Pklr-Myc)73Ak

neoplasm

increased metastatic potential ( J:184496 )

• 40% of double mutants exhibit lung metastasis which is not seen in single Tg(Pklr-Myc)73Ak mice

increased malignant tumor incidence ( J:184496 )

• tumors have higher grades of malignancy and are less differentiated than those of single Tg(Pklr-Myc)73Ak mice

increased hepatocellular carcinoma incidence ( J:184496 )

• mutants develop hepatocellular carcinoma (HCC); stronger promotion of initiation and progression steps of HCC development compared to single Tg(Pklr-Myc)73Ak mice

• the number and size of tumor nodules in double mutants is greater than in single Tg(Pklr-Myc)73Ak mice

• some tumors in double mutants exhibit a very poorly differentiated phenotype (fetal-like phenotype) that is never seen in tumors of single Tg(Pklr-Myc)73Ak mice

• tumors have higher mitotic indices compared with tumors from single Tg(Pklr-Myc)73Ak mice

liver/biliary system

increased hepatocellular carcinoma incidence ( J:184496 )

• mutants develop hepatocellular carcinoma (HCC); stronger promotion of initiation and progression steps of HCC development compared to single Tg(Pklr-Myc)73Ak mice

• the number and size of tumor nodules in double mutants is greater than in single Tg(Pklr-Myc)73Ak mice

• some tumors in double mutants exhibit a very poorly differentiated phenotype (fetal-like phenotype) that is never seen in tumors of single Tg(Pklr-Myc)73Ak mice

• tumors have higher mitotic indices compared with tumors from single Tg(Pklr-Myc)73Ak mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:184496

Genotype
MGI:5430592

tg3

• Allelic Composition: Tg(Pklr-Myc)73Ak/0
• Genetic Background: B6.Cg-Tg(Pklr-Myc)73Ak

neoplasm

increased hepatocellular carcinoma incidence ( J:184496 )

immune system

decreased NK T cell number ( J:184496 )

• the proportion of invariant NKT cells in the liver is lower than in controls

hematopoietic system

decreased NK T cell number ( J:184496 )

• the proportion of invariant NKT cells in the liver is lower than in controls

liver/biliary system

increased hepatocellular carcinoma incidence ( J:184496 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:184496

Genotype
MGI:5428914

tg4

• Allelic Composition: Tg(Pklr-Myc)73Ak/0
• Genetic Background: involves: C57BL/6 * DBA

neoplasm

increased hepatocellular carcinoma incidence ( J:185488 )

• mutants fed a carbohydrate-rich diet develop hepatocarcinomas

• frequency of hepatocarcinomas is positively correlated with the carbohydrate content of the diet; frequency increases from 14.3% to 31.7% and 65.2% when the carbohydrate ratio is increased from 10% to 50% to 75%, respectively

increased hepatoma incidence ( J:185488 )

• mutants fed a carbohydrate-rich diet frequently develop hepatomas

endocrine/exocrine glands

pancreatic islet hyperplasia ( J:185488 )

• mutants fed a carbohydrate-rich diet exhibit pancreatic islet hyperplasia, however they do not develop pancreatic tumors

liver/biliary system

increased hepatocellular carcinoma incidence ( J:185488 )

• mutants fed a carbohydrate-rich diet develop hepatocarcinomas

• frequency of hepatocarcinomas is positively correlated with the carbohydrate content of the diet; frequency increases from 14.3% to 31.7% and 65.2% when the carbohydrate ratio is increased from 10% to 50% to 75%, respectively

increased hepatoma incidence ( J:185488 )

• mutants fed a carbohydrate-rich diet frequently develop hepatomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:185488