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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nuak1tm1Esu
targeted mutation 1, Hiroyasu Esumi
MGI:5428915
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Nuak1tm1Esu/Nuak1tm1Esu
Tg(Ckmm-cre)5Khn/0
B6.Cg-Nuak1tm1Esu Tg(Ckmm-cre)5Khn MGI:5428916


Genotype
MGI:5428916
cn1
Allelic
Composition
Nuak1tm1Esu/Nuak1tm1Esu
Tg(Ckmm-cre)5Khn/0
Genetic
Background
B6.Cg-Nuak1tm1Esu Tg(Ckmm-cre)5Khn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nuak1tm1Esu mutation (0 available); any Nuak1 mutation (44 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
N
• no differences are detected in heart or soleus muscle weights and soleus myocyte cross sections are similar to controls on both normal chow and high fat diets
• in soleus muscle cells from mice on a high fat diet glucose uptake is similar to mice on a normal chow diet unlike in wild-type mice where the high fat diet impairs glucose uptake
• in mice fed a normal chow or high fat diet compared to diet matched controls

homeostasis/metabolism
• in mice on a high fat diet, fasting glucose levels are reduced at 13 - 15 and 18-19 weeks of age compared to diet matched controls
• no difference in glucose levels compared to controls is detected in mice on a normal chow diet
• in mice on a high fat diet compared to diet matched controls
• in mice fed a normal chow or high fat diet compared to diet matched controls
• in mice on a high fat diet compared to diet matched controls

cellular
• in soleus muscle cells from mice on a high fat diet glucose uptake is similar to mice on a normal chow diet unlike in wild-type mice where the high fat diet impairs glucose uptake





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory