Phenotypes associated with this allele

• Allele Symbol: Bid^tm1.1Atgr
• Allele Name: targeted mutation 1.1, Atan Gross
• Allele ID: MGI:5428930
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bid^tm1.1Atgr/Bid^tm1.1Atgr	B6.129-Bid^tm1.1Atgr	MGI:5428932

Genotype
MGI:5428932

hm1

• Allelic Composition: Bid^tm1.1Atgr/Bid^tm1.1Atgr
• Genetic Background: B6.129-Bid^tm1.1Atgr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased mortality induced by ionizing radiation ( J:185449 )

• increased lethality relative to controls after 7 Gy or more of total body irradiation

• antioxidant N-acetyl-L-cysteine treatment of mice has a protective affect on lethality due to radiation

hematopoietic system

abnormal bone marrow cell physiology ( J:185449 )

• less colony formation using bone marrow cells taken 7 days after 5 Gy of total body irradiation

• bone marrow cells at a competitive disadvantage in repopulating bone marrow of lethally irradiated mice

abnormal hematopoietic stem cell physiology ( J:185449 )

• acute decrease in stem cell numbers 1-10 days after whole body irradiation

• increased apoptosis after whole body irradiation

• increased stem cell proliferation after whole body irradiation and fewer quiescent stage cells

• antioxidant N-acetyl-L-cysteine treatment of mice reduces proliferation

homeostasis/metabolism

increased mortality induced by ionizing radiation ( J:185449 )

• increased lethality relative to controls after 7 Gy or more of total body irradiation

• antioxidant N-acetyl-L-cysteine treatment of mice has a protective affect on lethality due to radiation