Phenotypes associated with this allele

• Allele Symbol: Aim2^tm1.1Vmd
• Allele Name: targeted mutation 1.1, Vishva M Dixit
• Allele ID: MGI:5428935
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aim2^tm1.1Vmd/Aim2^tm1.1Vmd	C57BL/6-Aim2^tm1.1Vmd	MGI:5428936

Genotype
MGI:5428936

hm1

• Allelic Composition: Aim2^tm1.1Vmd/Aim2^tm1.1Vmd
• Genetic Background: C57BL/6-Aim2^tm1.1Vmd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:160545 )

• improved cell viability following transfection with poly(dA:dT) or pcDNA3

• improved bone marrow derived macrophage viability following infection with F. tularensis

abnormal cytokine secretion ( J:160545 )

increased interferon-beta secretion ( J:160545 )

• in bone marrow derived macrophages stimulated by poly(dA:dT) or pcDNA3

decreased interleukin-1 beta secretion ( J:160545 )

• in LPS-primed bone marrow derived macrophages or peritoneal macrophages stimulated by dsDNA

• bone marrow derived macrophages do not secrete IL1B in response to F. tularensis

decreased interleukin-18 secretion ( J:160545 )

• in LPS-primed bone marrow derived macrophages stimulated by dsDNA

increased tumor necrosis factor secretion ( J:160545 )

• in bone marrow derived macrophages stimulated by poly(dA:dT) or pcDNA3

increased susceptibility to bacterial infection ( J:160545 )

• fail to control F. tularensis infection

hematopoietic system

abnormal macrophage physiology ( J:160545 )

• improved cell viability following transfection with poly(dA:dT) or pcDNA3

• improved bone marrow derived macrophage viability following infection with F. tularensis