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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Id2tm1Xdz
targeted mutation 1, Xu-Dong Zhao
MGI:5428940
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Id1tm3Bene/Id1tm3Bene
Id2tm1Xdz/Id2tm1Xdz
Id3tm1Zhu/Id3tm1Zhu 		involves: 129S4/SvJaeSor * C57BL/6 MGI:5428955
cn2
 		Id1tm3Bene/Id1tm3Bene
Id2tm1Xdz/Id2tm1Xdz
Id3tm1Zhu/Id3tm1Zhu
Tg(Nes-cre)1Kln/0 		involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:5428946
cn3
 		Id1tm3Bene/Id1tm3Bene
Id2tm1Xdz/Id2+
Id3tm1Zhu/Id3tm1Zhu
Tg(Nes-cre)1Kln/0 		involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:5428947


Genotype
MGI:5428955
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Id1tm3Bene/Id1tm3Bene
Id2tm1Xdz/Id2tm1Xdz
Id3tm1Zhu/Id3tm1Zhu
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Thl mutation (0 available); any Gt(ROSA)26Sor mutation (1006 available)
Id1tm3Bene mutation (0 available); any Id1 mutation (10 available)
Id2tm1Xdz mutation (0 available); any Id2 mutation (21 available)
Id3tm1Zhu mutation (1 available); any Id3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
premature neuronal precursor differentiation ( J:185426 )
• following tamoxifen-treatment of cultured neural stem cells

nervous system
premature neuronal precursor differentiation ( J:185426 )
• following tamoxifen-treatment of cultured neural stem cells




Genotype
MGI:5428946
cn2
Allelic
Composition		 Id1tm3Bene/Id1tm3Bene
Id2tm1Xdz/Id2tm1Xdz
Id3tm1Zhu/Id3tm1Zhu
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id1tm3Bene mutation (0 available); any Id1 mutation (10 available)
Id2tm1Xdz mutation (0 available); any Id2 mutation (21 available)
Id3tm1Zhu mutation (1 available); any Id3 mutation (16 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:185426 )
• nearly all mice die within the first 24 hours after birth

nervous system
abnormal neuron differentiation ( J:185426 )
• at E18.5, neuronal stem cells exhibit altered shape at the apical border compared with control cells
• cultured neural stem cells fail to form primary and secondary neurospheres unlike control cells
premature neuronal precursor differentiation ( J:185426 )
• of neural stem cells in vitro and in vivo as determined by marker expression
abnormal neuronal precursor proliferation ( J:185426 )
• at E18.5, neural stem cell proliferation is reduced with prolonged cell cycle timing and increased probability of exiting the cell cycle compared with control cells
abnormal brain morphology ( J:185426 )
• hypocellular at E18.5 and P0
abnormal cortical ventricular zone morphology ( J:185426 )
• disrupted pseudo-stratified architecture at E18.5
enlarged brain ventricles ( J:185426 )
• at E18.5 and P0

cellular
abnormal cell cycle ( J:185426 )
• at E18.5, neural stem cell proliferation is reduced with prolonged cell cycle timing and increased probability of exiting the cell cycle compared with control cells
abnormal neuron differentiation ( J:185426 )
• at E18.5, neuronal stem cells exhibit altered shape at the apical border compared with control cells
• cultured neural stem cells fail to form primary and secondary neurospheres unlike control cells
premature neuronal precursor differentiation ( J:185426 )
• of neural stem cells in vitro and in vivo as determined by marker expression
abnormal neuronal precursor proliferation ( J:185426 )
• at E18.5, neural stem cell proliferation is reduced with prolonged cell cycle timing and increased probability of exiting the cell cycle compared with control cells




Genotype
MGI:5428947
cn3
Allelic
Composition		 Id1tm3Bene/Id1tm3Bene
Id2tm1Xdz/Id2+
Id3tm1Zhu/Id3tm1Zhu
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id1tm3Bene mutation (0 available); any Id1 mutation (10 available)
Id2tm1Xdz mutation (0 available); any Id2 mutation (21 available)
Id3tm1Zhu mutation (1 available); any Id3 mutation (16 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:185426 )
N
• neural stem cells exhibit normal self-renewal and proliferation




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory