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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ruvbl2M1Btlr
mutation 1, Bruce Beutler
MGI:5428996
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ruvbl2M1Btlr/Ruvbl2M1Btlr involves: C57BL/6J MGI:5429176
ht2
 		Ruvbl2M1Btlr/Ruvbl2+ involves: C57BL/6J MGI:5429177


Genotype
MGI:5429176
hm1
Allelic
Composition		 Ruvbl2M1Btlr/Ruvbl2M1Btlr
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ruvbl2M1Btlr mutation (1 available); any Ruvbl2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality, complete penetrance ( J:185495 )
• no mice are recovered




Genotype
MGI:5429177
ht2
Allelic
Composition		 Ruvbl2M1Btlr/Ruvbl2+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ruvbl2M1Btlr mutation (1 available); any Ruvbl2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:185495 )
N
• mice exhibit a normal response to NP-Ficoll
• B cell development is normal
abnormal class switch recombination ( J:185495 )
• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice
decreased T cell number ( J:185495 )
• T cell deficiency
decreased IgG level ( J:185495 )
• response in response to recombinant Semliki Forest virus (SFV) encoded antigen
decreased IgG1 level ( J:185495 )
• 7 days following NP-CGG immunization
• however, levels were normal by day 14
decreased IgM level ( J:185495 )
• 7 days following NP-CGG immunization
• however, levels were normal by day 14

pigmentation

hematopoietic system
abnormal class switch recombination ( J:185495 )
• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice
decreased T cell number ( J:185495 )
• T cell deficiency
decreased IgG level ( J:185495 )
• response in response to recombinant Semliki Forest virus (SFV) encoded antigen
decreased IgG1 level ( J:185495 )
• 7 days following NP-CGG immunization
• however, levels were normal by day 14
decreased IgM level ( J:185495 )
• 7 days following NP-CGG immunization
• however, levels were normal by day 14

integument

endocrine/exocrine glands




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory