Phenotypes associated with this allele

• Allele Symbol: Rag1^m2Btlr
• Allele Name: mutation 2, Bruce Beutler
• Allele ID: MGI:5429068
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rag1^m2Btlr/Rag1^m2Btlr	involves: C57BL/6J	MGI:5429181

Genotype
MGI:5429181

hm1

• Allelic Composition: Rag1^m2Btlr/Rag1^m2Btlr
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

decreased B cell number ( J:185495 )

• B cell deficiency

decreased T cell number ( J:185495 )

• T cell deficiency

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

decreased IgM level ( J:185495 )

• following NP-Ficoll immunization

hematopoietic system

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

decreased B cell number ( J:185495 )

• B cell deficiency

decreased T cell number ( J:185495 )

• T cell deficiency

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

decreased IgM level ( J:185495 )

• following NP-Ficoll immunization