Phenotypes associated with this allele

• Allele Symbol: Ulk4^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:5429194
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ulk4^tm1Lex/Ulk4^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:5429215

Genotype
MGI:5429215

hm1

• Allelic Composition: Ulk4^tm1Lex/Ulk4^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:185566 )

• majority die before reaching 4 months of age

growth/size/body

decreased body size ( J:185566 )

• all mutants smaller than control littermates

craniofacial

domed cranium ( J:185566 )

• domed heads

nervous system

intraventricular hemorrhage ( J:185566 )

• hemorrhage in lateral and third ventricles

hydrocephaly ( J:185566 )

abnormal brain ependyma morphology ( J:185566 )

• hemorrhage sometimes accompanied by fibrosis and neovascularization of choroid and meninges

decreased brain ependyma motile cilium length ( J:185566 )

• ependymal cilia are shorter than controls

dilated lateral ventricle ( J:185566 )

• marked to severe dilation of lateral ventricles

abnormal choroid plexus morphology ( J:185566 )

• hemorrhage sometimes accompanied by fibrosis and neovascularization of choroid and meninges

dilated third ventricle ( J:185566 )

• marked to severe dilation of third ventricle

immune system

increased susceptibility to otitis media ( J:185566 )

• suppurative otitis media is seen in many animals

nasal inflammation ( J:185566 )

• nasal passages partially filled with combinations of proteinaceous fluid or suppurative exudates

maxillary sinus inflammation ( J:185566 )

• maxillary sinuses partially filled with combinations of proteinaceous fluid or suppurative exudates

respiratory system

abnormal respiratory motile cilium morphology ( J:185566 )

• respiratory epithelial cilia are shorter than controls

nasal inflammation ( J:185566 )

• nasal passages partially filled with combinations of proteinaceous fluid or suppurative exudates

maxillary sinus inflammation ( J:185566 )

• maxillary sinuses partially filled with combinations of proteinaceous fluid or suppurative exudates

cellular

decreased brain ependyma motile cilium length ( J:185566 )

• ependymal cilia are shorter than controls

abnormal respiratory motile cilium morphology ( J:185566 )

• respiratory epithelial cilia are shorter than controls

cardiovascular system

intraventricular hemorrhage ( J:185566 )

• hemorrhage in lateral and third ventricles

hearing/vestibular/ear

increased susceptibility to otitis media ( J:185566 )

• suppurative otitis media is seen in many animals

skeleton

domed cranium ( J:185566 )

• domed heads

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hydrocephalus		DOID:10908	OMIM:123155 OMIM:236600 OMIM:236635 OMIM:307000 OMIM:615219	J:185566