Phenotypes associated with this allele

• Allele Symbol: Stk36^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:5429196
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stk36^tm1Lex/Stk36^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:5429551

Genotype
MGI:5429551

hm1

• Allelic Composition: Stk36^tm1Lex/Stk36^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal craniofacial morphology ( J:185566 )

growth/size/body

growth/size/body region phenotype ( J:185566 )

N • notably, situs inversus was not detected

decreased body weight ( J:185566 )

decreased body length ( J:185566 )

• reduced mean body length

postnatal growth retardation ( J:185566 )

hearing/vestibular/ear

increased susceptibility to otitis media ( J:185566 )

• bilateral suppurative otitis media is seen

immune system

increased susceptibility to otitis media ( J:185566 )

• bilateral suppurative otitis media is seen

mortality/aging

premature death ( J:185566 )

• mice are sickly, with most dying or euthanized between 3- 6 weeks of age; some survived to 12 weeks

nervous system

hydrocephaly ( J:185566 )

reproductive system

female infertility ( J:185566 )

♀ • of 2 females tested, both were sterile; males were not available for analysis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hydrocephalus		DOID:10908	OMIM:123155 OMIM:236600 OMIM:236635 OMIM:307000 OMIM:615219	J:185566