Phenotypes associated with this allele

• Allele Symbol: Cdk7^{Gt(D032B11)1.1Wrst}
• Allele Name: gene trap D032B11, 1.1, German Gene Trap Consortium
• Allele ID: MGI:5429213
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cdk7^Gt(D032B11)1.1Wrst/Cdk7^Gt(D032B11)1.1Wrst	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:5429235
cn2	Cdk7^Gt(D032B11)1.1Wrst/Cdk7^Gt(D032B11)1.1Wrst Ndor1^Tg(UBC-cre/ERT2)1Ejb/0	involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL	MGI:5429245
cn3	Cdk7^Gt(D032B11)1.1Wrst/Cdk7^Gt(D032B11)1.1Wrst Tg(KRT5-cre)1Tak/0	involves: 129S2/SvPas * C3H * C57BL/6 * SJL	MGI:5429230

Genotype
MGI:5429235

cn1

• Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst}
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

absent fibroblast proliferation ( J:183925 )

• MEF's infected with adenoviral cre fail to proliferate after serum stimulation

Genotype
MGI:5429245

cn2

• Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst}; Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0
• Genetic Background: involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL

mortality/aging

premature aging ( J:183925 )

• at 8 months of age in mice exposed to a tamoxifen diet from weaning

growth/size/body

weight loss ( J:183925 )

• significant weight loss at 8 months of age in mice exposed to a tamoxifen diet from weaning

digestive/alimentary system

abnormal small intestine crypts of Lieberkuhn morphology ( J:183925 )

• hypoplastic crypts at 8 months of age in mice exposed to a tamoxifen diet from weaning

decreased small intestinal villus size ( J:183925 )

• hypoplastic villi at 8 months of age in mice exposed to a tamoxifen diet from weaning

integument

decreased subcutaneous adipose tissue amount ( J:183925 )

• at 8 months of age in mice exposed to a tamoxifen diet from weaning

abnormal coat/hair pigmentation ( J:183925 )

• pervasive hair graying at 8 months of age in mice exposed to a tamoxifen diet from weaning

alopecia ( J:183925 )

• diffuse alopecia at 8 months of age in mice exposed to a tamoxifen diet from weaning

abnormal hair follicle morphology ( J:183925 )

• transformation of follicular epithelium into sebaceous glands at 8 months of age in mice exposed to a tamoxifen diet from weaning

abnormal hair follicle bulge morphology ( J:183925 )

• depletion of epithelial stem cells at 8 months of age in mice exposed to a tamoxifen diet from weaning

abnormal skin morphology ( J:183925 )

• reduction in average telomere length in skin cells at 8 months of age in mice exposed to a tamoxifen diet from weaning

thin dermal layer ( J:183925 )

• reduced dermal thickness at 8 months of age in mice exposed to a tamoxifen diet from weaning

skeleton

kyphosis ( J:183925 )

• at 8 months of age in mice exposed to a tamoxifen diet from weaning

abnormal bone marrow morphology ( J:183925 )

• some bone marrow is replaced by adipose tissue in mice at 8 months of age exposed to a tamoxifen diet from weaning

decreased bone mineral content ( J:183925 )

• at 8 months of age in mice exposed to a tamoxifen diet from weaning

decreased trabecular bone mass ( J:183925 )

• at 8 months of age in mice exposed to a tamoxifen diet from weaning

renal/urinary system

abnormal kidney morphology ( J:183925 )

• progressive nephropathy at 8 months of age in mice exposed to a tamoxifen diet from weaning

nephrocalcinosis ( J:183925 )

• severe medullary calcification at 8 months of age in mice exposed to a tamoxifen diet from weaning

hematopoietic system

decreased hematopoietic stem cell number ( J:183925 )

• at 8 months of age in mice exposed to a tamoxifen diet from weaning

pigmentation

abnormal coat/hair pigmentation ( J:183925 )

• pervasive hair graying at 8 months of age in mice exposed to a tamoxifen diet from weaning

adipose tissue

decreased subcutaneous adipose tissue amount ( J:183925 )

• at 8 months of age in mice exposed to a tamoxifen diet from weaning

endocrine/exocrine glands

abnormal small intestine crypts of Lieberkuhn morphology ( J:183925 )

• hypoplastic crypts at 8 months of age in mice exposed to a tamoxifen diet from weaning

cellular

decreased telomere length ( J:183925 )

• reduction in average telomere length in skin cells at 8 months of age in mice exposed to a tamoxifen diet from weaning

Genotype
MGI:5429230

cn3

• Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst}; Tg(KRT5-cre)1Tak/0
• Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6 * SJL

mortality/aging

postnatal lethality, complete penetrance ( J:183925 )

• die between P1 and P4

integument

sparse hair ( J:183925 )

• widespread lack of hair

decreased hair follicle number ( J:183925 )

• severe decrease in hypoplastic epidermal regions

abnormal epidermal layer morphology ( J:183925 )

• the epidermis shows scattered hyperplastic and hypoplastic regions

• cells in hyperplastic regions continue to express Cdk7 whiles those in hypoplastic regions do not

abnormal epidermis suprabasal layer morphology ( J:183925 )

• hyperplastic regions show an expansion of keratin K5 expressing cells into the suprabasal layer and disorganization of these layers

thin epidermis suprabasal layer ( J:183925 )

• in hypoplastic regions

abnormal keratinocyte morphology ( J:183925 )

• hyperplastic regions show an expansion of keratin K5 expressing cells into the suprabasal layer and disorganization of these layers

scaly skin ( J:183925 )

abnormal skin development ( J:183925 )

• hypoplastic epidermal regions show delayed development and an abnormal differentiation pattern

growth/size/body

decreased birth body size ( J:183925 )