Phenotypes associated with this allele

• Allele Symbol: Atl1^tm1Jfnk
• Allele Name: targeted mutation 1, John Fink
• Allele ID: MGI:5429535
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atl1^tm1Jfnk/Atl1^tm1Jfnk	involves: 129S1/Sv * 129X1/SvJ	MGI:5429536

Genotype
MGI:5429536

hm1

• Allelic Composition: Atl1^tm1Jfnk/Atl1^tm1Jfnk
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal gait ( J:72410 )

• homozygous animals show a gait disturbance characterized by external rotation of the hind feet with footprint analysis

• show a trend toward decreased performance on rotorod and grid-walking with increasing age compared to controls, although this difference is not statistically significant

• large variation in the performance of heterozygous animals on rotorod, gridwalking and footprint analysis with some animals appearing normal while others show decreased motor abilities in these tests

limbs/digits/tail

abnormal autopod rotation ( J:72410 )

• external rotation of the hind feet