Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Pklr-SV40)1Ak transgene insertion 1, Axel Kahn MGI:5429578 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants develop pancreatic tumors as early as 4 months of age, even when fed a regular diet
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• mutants develop pancreatic tumors as early as 4 months of age, even when fed a regular diet
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants frequently die as a result of deep hypoglycemic accidents
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• 84% of mutants fed a carbohydrate-rich diet exhibit tumors of the endocrine pancreas; tumors are at first well delimited but later the conjunctive capsule is disrupted and proliferating cells infiltrate the peripheral tissue (exocrine acini or adipose cells) and in late stage, tumors are very aggressive with metastases to liver, stomach, kidney or lung in more than 80% of tumors
• pancreatic carcinomas in mutants fed a carbohydrate-rich diet are preceded by hyperplasia of the islets, then adenomas
• frequency of pancreatic tumors is positively correlated with the carbohydrate content of the diet; frequency increases from 14% to 36.9% and 84% when carbohydrates are increased from 10% to 50% and 75%, respectively
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• tumors consist mostly of insulin-secreting cells, although some also synthesized glucagon
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• 14.5% of mutants fed a carbohydrate-rich diet develop primary hepatocarcinomas
• frequency of hepatocarcinomas is positively correlated with the carbohydrate content of the diet; frequency increases from 6% to 10.2% and 14.5% when the carbohydrate ratio is increased from 10% to 50% to 75%, respectively
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• mutants fed a carbohydrate-rich diet frequently develop hepatomas
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• mutants fed a carbohydrate-rich diet develop primary kidney adenocarcinoma on a rare occasion
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• 8.2% of mutants develop maxillary osteosarcomas, regardless of diet
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• mutants fed a carbohydrate-rich diet that exhibit islet hyperplasia or pancreatic tumors show an abnormally high ratio of plasma insulin to glucose
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• mutants fed 10% carbohydrates show no or late occurrence of islet hyperplasia while mutants fed 75% carbohydrate diet show precocious diffuse hyperplasia of the islets
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• 84% of mutants fed a carbohydrate-rich diet exhibit tumors of the endocrine pancreas; tumors are at first well delimited but later the conjunctive capsule is disrupted and proliferating cells infiltrate the peripheral tissue (exocrine acini or adipose cells) and in late stage, tumors are very aggressive with metastases to liver, stomach, kidney or lung in more than 80% of tumors
• pancreatic carcinomas in mutants fed a carbohydrate-rich diet are preceded by hyperplasia of the islets, then adenomas
• frequency of pancreatic tumors is positively correlated with the carbohydrate content of the diet; frequency increases from 14% to 36.9% and 84% when carbohydrates are increased from 10% to 50% and 75%, respectively
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• tumors consist mostly of insulin-secreting cells, although some also synthesized glucagon
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• 8.2% of mutants develop maxillary osteosarcomas, regardless of diet
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• 14.5% of mutants fed a carbohydrate-rich diet develop primary hepatocarcinomas
• frequency of hepatocarcinomas is positively correlated with the carbohydrate content of the diet; frequency increases from 6% to 10.2% and 14.5% when the carbohydrate ratio is increased from 10% to 50% to 75%, respectively
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• mutants fed a carbohydrate-rich diet frequently develop hepatomas
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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