All Phenotypes Tg(HLA-DR2)#Lfug MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(HLA-DR2)#Lfug
transgene insertion, Lars Fugger
MGI:5429698

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(HLA-DR2)#Lfug/0 Tg(TCROb.1A12)#Lfug/0	involves: C57BL/6 * DBA/2	MGI:5429703
cx2	Rag2^tm1.1Cgn/Rag2^tm1.1Cgn Tg(HLA-DR2)#Lfug/0 Tg(TCROb.1A12)#Lfug/0	involves: C57BL/6 * DBA/2	MGI:5429705
cx3	Tg(Cd4-CD4)2362Litt/0 Tg(HLA-DR2)#Lfug/0 Tg(TCROb.1A12)#Lfug/0	involves: C57BL/6 * DBA/2 * SJL	MGI:5429704

Allelic Composition	Tg(HLA-DR2)#Lfug/0 Tg(TCROb.1A12)#Lfug/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:134764 )

• some mice die due to advanced disease during the onset of disease following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

immune system

increased susceptibility to experimental autoimmune encephalomyelitis ( J:134764 )

• following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin 85-90% of mice develop disease

• onset, clinical manifestations and course of disease are highly variable

• some mice die due to advanced disease during the onset of disease others develop a relapsing-remitting disease after the first attack

CNS inflammation ( J:134764 )

• spinal inflammation following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:134764 )

• following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin mice show one or more behavioral abnormalities indicative of white matter defects

lethargy ( J:134764 )

• drowsy

impaired balance ( J:134764 )

impaired coordination ( J:134764 )

abnormal locomotor activation ( J:134764 )

• slow movement

abnormal locomotor coordination ( J:134764 )

• spasticity

abnormal gait ( J:134764 )

• staggering gait

forelimb paralysis ( J:134764 )

hindlimb paralysis ( J:134764 )

• develops spontaneously in a few (4%) mice

nervous system

CNS inflammation ( J:134764 )

• spinal inflammation following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple sclerosis		DOID:2377	OMIM:612594 OMIM:612595 OMIM:612596	J:134764

Allelic Composition	Rag2^tm1.1Cgn/Rag2^tm1.1Cgn Tg(HLA-DR2)#Lfug/0 Tg(TCROb.1A12)#Lfug/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2^tm1.1Cgn mutation (4 available); any Rag2 mutation (119 available)
Tg(HLA-DR2)#Lfug mutation (0 available)
Tg(TCROb.1A12)#Lfug mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

autoimmune response ( J:134764 )

• clinical manifestations included both classical and non-classical EAE symptoms

CNS inflammation ( J:134764 )

• focal inflammatory lesions are seen throughout the central nervous system

• inflammatory infiltrate with variable cellular composition, usually containing neutrophilic granulocytes, activated macrophages and T lymphocytes

behavior/neurological

hindlimb paralysis ( J:134764 )

• seen in all mice with an age of onset ranging from 48 to 102 days

nervous system

CNS inflammation ( J:134764 )

• focal inflammatory lesions are seen throughout the central nervous system

• inflammatory infiltrate with variable cellular composition, usually containing neutrophilic granulocytes, activated macrophages and T lymphocytes

demyelination ( J:134764 )

• focal demyelinated tissue lesions are seen throughout the central nervous system, including the optic and vestibular nerves

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple sclerosis		DOID:2377	OMIM:612594 OMIM:612595 OMIM:612596	J:134764

Allelic Composition	Tg(Cd4-CD4)2362Litt/0 Tg(HLA-DR2)#Lfug/0 Tg(TCROb.1A12)#Lfug/0
Genetic Background	involves: C57BL/6 * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-CD4)2362Litt mutation (3 available)
Tg(HLA-DR2)#Lfug mutation (0 available)
Tg(TCROb.1A12)#Lfug mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:134764 )

• some mice die due to advanced disease during the onset of disease following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

immune system

increased susceptibility to experimental autoimmune encephalomyelitis ( J:134764 )

• following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin 85-90% of mice develop disease

• onset, clinical manifestations and course of disease are highly variable

• some mice die due to advanced disease during the onset of disease others develop a relapsing-remitting disease after the first attack

CNS inflammation ( J:134764 )

• spinal inflammation following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:134764 )

• following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin mice show one or more behavioral abnormalities indicative of white matter defects

lethargy ( J:134764 )

• drowsy

impaired balance ( J:134764 )

impaired coordination ( J:134764 )

abnormal locomotor activation ( J:134764 )

• slow movement

abnormal locomotor coordination ( J:134764 )

• spasticity

abnormal gait ( J:134764 )

• staggering gait

forelimb paralysis ( J:134764 )

nervous system

CNS inflammation ( J:134764 )

• spinal inflammation following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple sclerosis		DOID:2377	OMIM:612594 OMIM:612595 OMIM:612596	J:134764

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