Phenotypes associated with this allele

• Allele Symbol: Pmis2^tm1Osb
• Allele Name: targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• Allele ID: MGI:5429746
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pmis2^tm1Osb/Pmis2^tm1Osb	involves: 129 * C57BL/6	MGI:5429859
cx2	Pmis2^tm1Osb/Pmis2^tm1Osb Tg(Clgn-4930479M11Rik)#Osb/?	involves: 129 * C57BL/6 * DBA/2	MGI:5429860

Genotype
MGI:5429859

hm1

• Allelic Composition: Pmis2^tm1Osb/Pmis2^tm1Osb
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased fertilization frequency ( J:185714 )

• fertilization rate is "0"

impaired binding of sperm to zona pellucida ( J:185714 )

♂ • spermatozoa fail to bind to the zona pellucida

♂ • however, spermatozoa are able to fertilize eggs when added to cumulus-enclosed eggs

abnormal male reproductive system physiology ( J:185714 )

♂

impaired sperm migration in female genital tract ( J:185714 )

♂ • spermatozoa are unable to cross the utero-tubal junction

male infertility ( J:185714 )

♂ • males sire no pups although mating behavior is normal

cellular

impaired sperm migration in female genital tract ( J:185714 )

♂ • spermatozoa are unable to cross the utero-tubal junction

behavior/neurological

behavior/neurological phenotype ( J:185714 )

N • mating behavior normal

Genotype
MGI:5429860

cx2

• Allelic Composition: Pmis2^tm1Osb/Pmis2^tm1Osb; Tg(Clgn-4930479M11Rik)#Osb/?
• Genetic Background: involves: 129 * C57BL/6 * DBA/2

reproductive system

reproductive system phenotype ( J:185714 )

N • normal reproduction

N • infertility of males is rescued