Phenotypes associated with this allele

• Allele Symbol: Scn5a^{tm2.1(SCN5A)Rdn}
• Allele Name: targeted mutation 2.1, Dan M Roden
• Allele ID: MGI:5430150
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scn5a^tm2.1(SCN5A)Rdn/Scn5a^tm2.1(SCN5A)Rdn	involves: 129S6/SvEvTac	MGI:5430155

Genotype
MGI:5430155

hm1

• Allelic Composition: Scn5a^{tm2.1(SCN5A)Rdn}/Scn5a^{tm2.1(SCN5A)Rdn}
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:185686 )

N • mice exhibit normal responses to treatment with sodium channel blockers lidocaine and flecainide

shortened PR interval ( J:185686 )

shortened QRS complex duration ( J:185686 )

shortened QT interval ( J:185686 )

abnormal myocardial fiber physiology ( J:185686 )

• ventricular myocytes exhibit increases in functional sodium channels compared with myocytes from Scn5a^tm1Rdn homozygotes

• myocytes exhibit a negative shifts in the voltage dependence of sodium channel activation and inactivation compared with myocytes from Scn5a^tm1Rdn homozygotes