limbs/digits/tail
N |
• Background Sensitivity: unlike mice on a congenic C57BL/6 background, mice exhibit normal tails
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Allele Symbol Allele Name Allele ID |
Vangl2tm1.2Mdea targeted mutation 1.2, Michael R Deans MGI:5430219 |
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Summary |
5 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• Background Sensitivity: unlike mice on a congenic C57BL/6 background, mice exhibit normal tails
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|
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• in 6 of 23 mice
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• in most mice
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• Background Sensitivity: mice exhibit a disruption in the planar polarity of auditory hair cells compared with wild-type mice
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• along the length of the cochlea
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• mis-orientation with less mature apical positions
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• misoriented in field 2 of the utricles
• however, cells are normal in field 1 and 3
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• some mice exhibit incomplete or failed eyelid closure
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• Background Sensitivity: tail loops or kinks in 11 of 99 mice on a congenic C57BL/6 background unlike mice on congenic A/J or FVB/NCrl backgrounds
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• in 6 of 23 mice
|
• in most mice
|
• Background Sensitivity: mice exhibit a disruption in the planar polarity of auditory hair cells compared with wild-type mice
|
• along the length of the cochlea
|
• mis-orientation with less mature apical positions
|
• misoriented in field 2 of the utricles
• however, cells are normal in field 1 and 3
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• Background Sensitivity: unlike mice on a congenic C57BL/6 background, mice exhibit normal tails
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
Vestibular hair cell planar polarity defects in Vangl2tm1.2Mdea/Vangl2tm1.2Mdea and Vangl2tm1.2Mdea/Vangl2Lp mice
• more numerous and disorganized cells compared with Vangl2tm1.2Mdea homozygotes
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• reverse orientation
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• abnormal orientation in the mid to last rows
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• extra rows
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• more numerous and disorganized cells in more fields compared with Vangl2tm1.2Mdea homozygotes
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• more numerous and disorganized cells compared with Vangl2tm1.2Mdea homozygotes
|
• reverse orientation
|
• abnormal orientation in the mid to last rows
|
• extra rows
|
• more numerous and disorganized cells in more fields compared with Vangl2tm1.2Mdea homozygotes
|
|
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• cochlear length and number of turns are normal
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• misorientated
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• misorientated
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• shifted out of the second and third outer hair cell rows and not centrally positioned between the hair cell lateral edges
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• at P10 and P12, more pronounced in the apical turn
• more compact and incorrectly positioned compared with control mice
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• reduced ABR amplitude
• however, the overall shape of the waveform is normal
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• decreased amplitude of the distortion product
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• misorientated
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• misorientated
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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