Analysis Tools
mortality/aging
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• all mice die by P5 or P6
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nervous system
astrocytosis
(
J:185796
)
|
• at P5, mice exhibit astrocytic gliosis in the lumbar spinal cord
|
|
• in the lumbar and cervical spinal cord
|
|
• at P5, mice exhibit degeneration of 50% of lumbar motor neurons
• however, motor neuron numbers are normal between P0 and P3
|
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• motor neuron axons in the ventral root exhibits intra-axonal vacuoles, disintegrated myelin and lipids
• however, sensory neuron axons in the dorsal root are normal
|
cellular
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• mice exhibit increased endoplasmic reticulum stress in the spinal cord
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growth/size/body
