Analysis Tools
digestive/alimentary system
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• 3 days after tamoxifen treatment, some goblet cells express Paneth cell markers
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• between day 1 and 5 of tamoxifen treatment
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• tamoxifen-treated mice exhibit an absence of proliferative cells in the adult small intestine after 7 days of treatment
• cultured intestinal organoids treated with tamoxifen exhibit a block in proliferation and subsequent death of the organoid by day 6
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• 3 days after tamoxifen treatment, mice exhibit an elimination in Olfm4+ intestinal stem cells with the exception of in escaper crypts
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• 3 days after tamoxifen treatment, the small remaining Ki67+ escaper crypts contain limited numbers of correctly localized lysozyme-positive Paneth cells
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• 7 days after tamoxifen treatment, essentially all lysozyme-positive Paneth cells are eliminated
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• 3 days after tamoxifen treatment, Paneth cells are eliminated from the crypt of Lieberkuhn and aberrantly located on the villi
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cellular
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• 3 days after tamoxifen treatment, some goblet cells express Paneth cell markers
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• between day 1 and 5 of tamoxifen treatment
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• tamoxifen-treated mice exhibit an absence of proliferative cells in the adult small intestine after 7 days of treatment
• cultured intestinal organoids treated with tamoxifen exhibit a block in proliferation and subsequent death of the organoid by day 6
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endocrine/exocrine glands
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• 3 days after tamoxifen treatment, the small remaining Ki67+ escaper crypts contain limited numbers of correctly localized lysozyme-positive Paneth cells
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• 7 days after tamoxifen treatment, essentially all lysozyme-positive Paneth cells are eliminated
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• 3 days after tamoxifen treatment, Paneth cells are eliminated from the crypt of Lieberkuhn and aberrantly located on the villi
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