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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Pax6-HRAS*G12V)2044Ove
transgene insertion 2044, Paul A Overbeek
MGI:5430364
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ugdhtm1.1Xzh/Ugdhtm1.1Xzh
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Pax6-HRAS*G12V)2044Ove/0 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N MGI:5430384
tg2
 		Tg(Pax6-HRAS*G12V)2044Ove/0 involves: FVB/N MGI:5430365


Genotype
MGI:5430384
cn1
Allelic
Composition		 Ugdhtm1.1Xzh/Ugdhtm1.1Xzh
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Pax6-HRAS*G12V)2044Ove/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Tg(Pax6-HRAS*G12V)2044Ove mutation (0 available)
Ugdhtm1.1Xzh mutation (1 available); any Ugdh mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:185652 )
N
• robust lacrimal gland budding is seen unlike in mutant mice lacking Tg(Pax6-HRAS*G12V)2044Ove




Genotype
MGI:5430365
tg2
Allelic
Composition		 Tg(Pax6-HRAS*G12V)2044Ove/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Altered lens and corneal development inTg(Pax6-HRAS*G12V)2044Ove/0 mice

vision/eye
abnormal cornea epithelium morphology ( J:158529 )
• in the central cornea at E18.5
abnormal cornea stroma morphology ( J:158529 )
• in the central cornea at E18.5
abnormal eye development ( J:158529 )
• extra cells extending into the interior of the lens pit are seen at E10.5
• at E11.5, lenses and corneas display epithelial hyperplasia
• increase in proliferation of lens and corneal epithelial cells at E11.5 and E13.5
• expression analysis indicates abnormal differentiation of the cornea
abnormal lens development ( J:158529 )
• extra cells seen in the lens pit are internalized within the lumen of the lens at E11.5
• at E16.5 the lens epithelial show an elongated rather than cuboidal morphology
• expression analysis indicates abnormal differentiation of the lens
fused cornea and lens ( J:158529 )
• at E13.5 the lens is embedded in the cornea
• at E16.5 the lens remains attached to the cornea
lens vacuoles ( J:158529 )
• at E18.5
failure of eyelid fusion ( J:158529 )
• remain open at E16.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory