About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Taf7tm1.1Dss
targeted mutation 1.1, Dinah S Singer
MGI:5430372
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Taf7tm1.1Dss/Taf7tm1.1Dss involves: C57BL/6 MGI:5430374
cn2
 		Taf7tm1.1Dss/Taf7tm1.2Dss
Tg(Lck-cre)1Cwi/0 		involves: C57BL/6 MGI:5430375
cn3
 		Taf7tm1.1Dss/Taf7tm1.2Dss
Tg(Cd8a*-cre)B8Asin/0 		involves: C57BL/6 MGI:5430376


Genotype
MGI:5430374
hm1
Allelic
Composition		 Taf7tm1.1Dss/Taf7tm1.1Dss
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Taf7tm1.1Dss mutation (0 available); any Taf7 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:185745 )
• mice die between E3.5 and E5.5

embryo
abnormal embryo development ( J:185745 )
• mice either do not implant or expand




Genotype
MGI:5430375
cn2
Allelic
Composition		 Taf7tm1.1Dss/Taf7tm1.2Dss
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Taf7tm1.1Dss mutation (0 available); any Taf7 mutation (19 available)
Taf7tm1.2Dss mutation (0 available); any Taf7 mutation (19 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
small thymus ( J:185745 )
• very small
abnormal thymus physiology ( J:185745 )
• double negative thymocytes exhibit impaired proliferation
abnormal T cell differentiation ( J:185745 )
• mice exhibit defects in the transition from double negative to double positive thymocytes
increased double-negative T cell number ( J:185745 )
• slightly in the thymus

hematopoietic system
small thymus ( J:185745 )
• very small
abnormal thymus physiology ( J:185745 )
• double negative thymocytes exhibit impaired proliferation
abnormal T cell differentiation ( J:185745 )
• mice exhibit defects in the transition from double negative to double positive thymocytes
increased double-negative T cell number ( J:185745 )
• slightly in the thymus

endocrine/exocrine glands
small thymus ( J:185745 )
• very small
abnormal thymus physiology ( J:185745 )
• double negative thymocytes exhibit impaired proliferation




Genotype
MGI:5430376
cn3
Allelic
Composition		 Taf7tm1.1Dss/Taf7tm1.2Dss
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Taf7tm1.1Dss mutation (0 available); any Taf7 mutation (19 available)
Taf7tm1.2Dss mutation (0 available); any Taf7 mutation (19 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:185745 )
• after stimulation with either anti-CD3epsilon or a combination of anti-CD3 epsilon and anti-CD28 antibodies in the presence or absence of IL2
abnormal T cell differentiation ( J:185745 )
• modest effect on T cell development
• however, mice exhibit normal differentiation from double positive to single positive thymocyte and differentiation of single positive thymocytes
decreased T cell number ( J:185745 )
• in the lymph nodes
decreased thymocyte number ( J:185745 )
• at the double positive stage

hematopoietic system
decreased T cell proliferation ( J:185745 )
• after stimulation with either anti-CD3epsilon or a combination of anti-CD3 epsilon and anti-CD28 antibodies in the presence or absence of IL2
abnormal T cell differentiation ( J:185745 )
• modest effect on T cell development
• however, mice exhibit normal differentiation from double positive to single positive thymocyte and differentiation of single positive thymocytes
decreased T cell number ( J:185745 )
• in the lymph nodes
decreased thymocyte number ( J:185745 )
• at the double positive stage

endocrine/exocrine glands
decreased thymocyte number ( J:185745 )
• at the double positive stage

cellular
decreased T cell proliferation ( J:185745 )
• after stimulation with either anti-CD3epsilon or a combination of anti-CD3 epsilon and anti-CD28 antibodies in the presence or absence of IL2




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory