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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(NOTCH1/GFP)Xhsu
targeted mutation 1, Xiao-Hong Sun
MGI:5430379
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(NOTCH1/GFP)Xhsu/Gt(ROSA)26Sor+
Tg(Lck-cre)548Jxm/0 		B6.Cg-Gt(ROSA)26Sortm1(NOTCH1/GFP)Xhsu Tg(Lck-cre)548Jxm MGI:5432021


Genotype
MGI:5432021
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(NOTCH1/GFP)Xhsu/Gt(ROSA)26Sor+
Tg(Lck-cre)548Jxm/0
Genetic
Background		 B6.Cg-Gt(ROSA)26Sortm1(NOTCH1/GFP)Xhsu Tg(Lck-cre)548Jxm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(NOTCH1/GFP)Xhsu mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:185287 )
• median survival of 10 weeks

neoplasm
increased T cell derived lymphoma incidence ( J:185287 )
• large tumors with metastasis to lymph nodes, livers and/or kidney

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:185287 )
• large tumors with metastasis to lymph nodes, livers and/or kidney

immune system
increased T cell derived lymphoma incidence ( J:185287 )
• large tumors with metastasis to lymph nodes, livers and/or kidney

hematopoietic system
increased T cell derived lymphoma incidence ( J:185287 )
• large tumors with metastasis to lymph nodes, livers and/or kidney




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory