mortality/aging
• mice die shortly after birth
|
renal/urinary system
• multiple
|
• at E14.5, kidneys exhibit a thin cortical nephrogenic zone and poor nephron development
• mice exhibit depletion of nephron progenitors and premature tubule formation
• at E12.5, ectopic tubules are observed dorsal to the poorly branched ureteric bud-derived epithelia
|
• at E14.5, kidneys lack condensed metanephric mesenchyme around the ureteric buds in the cortex and contain few Pax2+ scattered tubules
|
• at E14.5, no ureteric bud-derived epithelia are observed in the mutant cortex
|
• thin cortical nephrogenic zone at E14.5
|
small kidney
(
J:185844
)
• at E14.5
• severe at birth
|
• some of the dilated tubules are positive for a proximal tubule marker
• however, proximal tubules are not overproduced
|
• at E14.5, ureteric bud branching is impaired
|
growth/size/body
• multiple
|