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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm2(Notch2)Ryn
targeted mutation 2, Ryuichi Nishinakamura
MGI:5430391
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6J MGI:5430442


Genotype
MGI:5430442
cn1
Allelic
Composition
Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Notch2)Ryn mutation (0 available); any Gt(ROSA)26Sor mutation (992 available)
Six2tm1(tTA,tetO-EGFP/cre)Amc mutation (0 available); any Six2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die shortly after birth

renal/urinary system
• at E14.5, kidneys exhibit a thin cortical nephrogenic zone and poor nephron development
• mice exhibit depletion of nephron progenitors and premature tubule formation
• at E12.5, ectopic tubules are observed dorsal to the poorly branched ureteric bud-derived epithelia
• at E14.5, kidneys lack condensed metanephric mesenchyme around the ureteric buds in the cortex and contain few Pax2+ scattered tubules
• at E14.5, no ureteric bud-derived epithelia are observed in the mutant cortex
• thin cortical nephrogenic zone at E14.5
• at E14.5
• severe at birth
• some of the dilated tubules are positive for a proximal tubule marker
• however, proximal tubules are not overproduced
• at E14.5, ureteric bud branching is impaired

growth/size/body





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory