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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ctnnb1tm1.2Wvv
targeted mutation 1.2, Wendy van Veelen
MGI:5430598
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ctnnb1tm1.2Wvv/Ctnnb1tm1.2Wvv involves: 129P2/OlaHsd * C57BL/6J MGI:5430608
ht2
 		Ctnnb1tm1.2Wvv/Ctnnb1+ involves: 129P2/OlaHsd * C57BL/6J MGI:5430609
cx3
 		Apctm1Rak/Apc+
Ctnnb1tm1.2Wvv/Ctnnb1+ 		involves: 129P2/OlaHsd * C57BL/6J MGI:5430610
cx4
 		Apctm2Rfo/Apc+
Ctnnb1tm1.2Wvv/Ctnnb1+ 		involves: 129P2/OlaHsd * C57BL/6J MGI:5430611


Genotype
MGI:5430608
hm1
Allelic
Composition		 Ctnnb1tm1.2Wvv/Ctnnb1tm1.2Wvv
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1.2Wvv mutation (0 available); any Ctnnb1 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:185942 )
• lethality around birth

craniofacial
abnormal cranium morphology ( J:185942 )
• dermal bones of the skull roof virtually absent
absent maxilla ( J:185942 )
• bones of the upper jaw virtually absent
abnormal mandibular prominence morphology ( J:185942 )
• mandible only mildly affected
abnormal maxillary prominence morphology ( J:185942 )
• primordia of upper jaw abnormal or absent
abnormal nasal capsule morphology ( J:185942 )
• primordia of nasal capsule abnormal or absent
abnormal tongue morphology ( J:185942 )
• tongue only mildly affected
facial cleft ( J:185942 )
• unfused facial processes

respiratory system
abnormal nasal capsule morphology ( J:185942 )
• primordia of nasal capsule abnormal or absent

skeleton
abnormal cranium morphology ( J:185942 )
• dermal bones of the skull roof virtually absent
absent maxilla ( J:185942 )
• bones of the upper jaw virtually absent
abnormal nasal capsule morphology ( J:185942 )
• primordia of nasal capsule abnormal or absent

digestive/alimentary system
abnormal tongue morphology ( J:185942 )
• tongue only mildly affected

growth/size/body
abnormal head morphology ( J:185942 )
abnormal nasal capsule morphology ( J:185942 )
• primordia of nasal capsule abnormal or absent
abnormal tongue morphology ( J:185942 )
• tongue only mildly affected
facial cleft ( J:185942 )
• unfused facial processes
abnormal anterior head development ( J:185942 )
• most rostral regions of the head are severely underdeveloped at E12.5
microcephaly ( J:185942 )
• smaller head at E10.5




Genotype
MGI:5430609
ht2
Allelic
Composition		 Ctnnb1tm1.2Wvv/Ctnnb1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1.2Wvv mutation (0 available); any Ctnnb1 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased gastrointestinal tumor incidence ( J:185942 )
• 14 tumors at 16-18 months in the duodenum and jejunum in 11 of 29 mice examined compared to none in controls
• 50% gastrointestinal intraepithelial neoplasia/adenoma
increased intestinal adenocarcinoma incidence ( J:185942 )
• 29% are dysplastic adenoma/carcinoma

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:185942 )
• 14 tumors at 16-18 months in the duodenum and jejunum in 11 of 29 mice examined compared to none in controls
• 50% gastrointestinal intraepithelial neoplasia/adenoma
increased intestinal adenocarcinoma incidence ( J:185942 )
• 29% are dysplastic adenoma/carcinoma




Genotype
MGI:5430610
cx3
Allelic
Composition		 Apctm1Rak/Apc+
Ctnnb1tm1.2Wvv/Ctnnb1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Rak mutation (1 available); any Apc mutation (158 available)
Ctnnb1tm1.2Wvv mutation (0 available); any Ctnnb1 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
rostral body truncation ( J:185942 )
• anterior truncation

nervous system
abnormal telencephalon development ( J:185942 )
• severe reduction in the telencephalic region of the brain




Genotype
MGI:5430611
cx4
Allelic
Composition		 Apctm2Rfo/Apc+
Ctnnb1tm1.2Wvv/Ctnnb1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2Rfo mutation (1 available); any Apc mutation (158 available)
Ctnnb1tm1.2Wvv mutation (0 available); any Ctnnb1 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
rostral body truncation ( J:185942 )
• anterior truncation




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory