Analysis Tools
mortality/aging
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• no mice survive past P1
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• decrease in frequency first seen at E15.5
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cardiovascular system
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• vascular integrity defects in internal organs; including the submandibular salivary gland and liver
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• telangiectasia at E15.5 in some embryos
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• in 50% of embryos at E18.5
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homeostasis/metabolism
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• in most embryos at E15.5
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limbs/digits/tail
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• in most mice at E12.5, E15.5, E18.5 and P1 only on the forelimbs
• characterized by the absence of the most posterior digit (5); some mice also lack digit 4
|
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• distal limb morphogenesis is defective in most embryos
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• loss of posterior forelimb bud at E12.5
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vision/eye
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• decrease in the size of the slow cycling band of cells in the mucocutaneous junction region
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• at E15.5 the projection of migrating periderm cells is severely diminished and remains incomplete at E16.5
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• in about half of the mice at E18.5 and P1
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nervous system
exencephaly
(
J:185554
)
|
• rare, at E15.5 and E18.5
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embryo
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• loss of posterior forelimb bud at E12.5
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