Phenotypes associated with this allele

• Allele Symbol: Tas1r1^tm1Uboe
• Allele Name: targeted mutation 1, Ulrich Boehm
• Allele ID: MGI:5430605
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tas1r1^tm1Uboe/Tas1r1^tm1Uboe	involves: C57BL/6	MGI:5430606

Genotype
MGI:5430606

hm1

• Allelic Composition: Tas1r1^tm1Uboe/Tas1r1^tm1Uboe
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:185286 )

N • fertile with normal testis weight, mature sperm numbers and sperm motility

multinucleated giant male germ cells ( J:185286 )

♂

increased male germ cell apoptosis ( J:185286 )

♂ • increase in apoptotic cells in the seminiferous tubules

abnormal seminiferous tubule morphology ( J:185286 )

♂ • mild perturbations in the defined spatial organization of developing germ cell populations are seen

♂ • miss-located spermatocytes in the luminal part of the seminiferous tubules instead of being restricted to the more basal cell layers

abnormal spermatogenesis ( J:185286 )

♂ • multinucleated giant cells are present in the tubules

abnormal sperm physiology ( J:185286 )

♂ • higher Ca²⁺ concentrations and cAMP levels in the sperm

premature acrosome reaction ( J:185286 )

♂ • increase in the incidence of spontaneous acrosome reaction

cellular

multinucleated giant male germ cells ( J:185286 )

♂

increased male germ cell apoptosis ( J:185286 )

♂ • increase in apoptotic cells in the seminiferous tubules

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:185286 )

♂ • mild perturbations in the defined spatial organization of developing germ cell populations are seen

♂ • miss-located spermatocytes in the luminal part of the seminiferous tubules instead of being restricted to the more basal cell layers