Phenotypes associated with this allele

• Allele Symbol: Ace^tm9Keb
• Allele Name: targeted mutation 9, Kenneth E Bernstein
• Allele ID: MGI:5430660
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ace^tm9Keb/Ace^tm9Keb	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5430728

Genotype
MGI:5430728

hm1

• Allelic Composition: Ace^tm9Keb/Ace^tm9Keb
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:185888 )

N • mice were analyzed in a mixed background lacking the Ren2 gene

N • mice exhibit normal intrarenal Ang I homeostasis

abnormal circulating angiotensinogen level ( J:185888 )

• the ratio of angiotensin II (Ang II) to angiotensin I (Ang I) is lower than in wild-type mice

• chronic angiotensin I infusion increases the ratio of Ang II to Ang I unlike in wild-type mice

decreased circulating angiotensinogen level ( J:185888 )

• in untreated and angiotensin I-treated mice

abnormal urine osmolality ( J:185888 )

• water-deprived mice fail to exhibit an increase in urine osmolality unlike wild-type mice

decreased urine osmolality ( J:185888 )

decreased angiotensin I-converting enzyme activity ( J:185888 )

• in the plasma and lungs, but not kidneys

increased renin activity ( J:185888 )

renal/urinary system

abnormal renal artery morphology ( J:185888 )

• thickened intrarenal arteries

abnormal urine osmolality ( J:185888 )

• water-deprived mice fail to exhibit an increase in urine osmolality unlike wild-type mice

decreased urine osmolality ( J:185888 )

kidney inflammation ( J:185888 )

• perivascular infiltrates

abnormal kidney medulla morphology ( J:185888 )

• thinned

abnormal kidney pelvis morphology ( J:185888 )

• variable degrees of pelvis expansion

polyuria ( J:185888 )

behavior/neurological

increased fluid intake ( J:185888 )

cardiovascular system

abnormal renal artery morphology ( J:185888 )

• thickened intrarenal arteries

abnormal systemic arterial blood pressure ( J:185888 )

• angiotensin I-infused mice exhibit a slow hypertensive response compared with wild-type mice

decreased systemic arterial systolic blood pressure ( J:185888 )

• in untreated and angiotensin I-treated mice

immune system

kidney inflammation ( J:185888 )

• perivascular infiltrates