Phenotypes associated with this allele

• Allele Symbol: Tg(INPP5B)CNbm
• Allele Name: transgene insertion C, Robert L Nussbaum
• Allele ID: MGI:5430746
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Inpp5b^tm1Nbm/Inpp5b^tm1Nbm Ocrl^tm1Nbm/Ocrl^tm1Nbm Tg(INPP5B)CNbm/0	involves: 129S/SvEv * 129S6/SvEvTac * FVB/N	MGI:5430751
cx2	Inpp5b^tm1Nbm/Inpp5b^tm1Nbm Ocrl^tm1Nbm/Y Tg(INPP5B)CNbm/0	involves: 129S/SvEv * 129S6/SvEvTac * FVB/N	MGI:5430752
cx3	Inpp5b^tm1Nbm/Inpp5b^tm1Nbm Ocrl^tm1Nbm/Ocrl^tm1Nbm Tg(INPP5B)CNbm/Tg(INPP5B)CNbm	involves: 129S/SvEv * 129S6/SvEvTac * FVB/N	MGI:5430753
cx4	Inpp5b^tm1Nbm/Inpp5b^tm1Nbm Ocrl^tm1Nbm/Y Tg(INPP5B)CNbm/Tg(INPP5B)CNbm	involves: 129S/SvEv * 129S6/SvEvTac * FVB/N	MGI:5430754

Genotype
MGI:5430751

cx1

• Allelic Composition: Inpp5b^tm1Nbm/Inpp5b^tm1Nbm; Ocrl^tm1Nbm/Ocrl^tm1Nbm; Tg(INPP5B)CNbm/0
• Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:185879 )

♀ • a few mice die by 6 weeks of age

growth/size/body

decreased birth body size ( J:185879 )

♀ • in a few mice

decreased body weight ( J:185879 )

♀

postnatal growth retardation ( J:185879 )

♀ • by 4 weeks

renal/urinary system

aminoaciduria ( J:185879 )

♀

increased urine microglobulin level ( J:185879 )

♀

vision/eye

vision/eye phenotype ( J:185879 )

♀N • mice exhibit normal lens development and do not develop cataracts

homeostasis/metabolism

aminoaciduria ( J:185879 )

♀

increased urine microglobulin level ( J:185879 )

♀

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Dent disease		DOID:0050699	OMIM:300009 OMIM:300555	J:185879
oculocerebrorenal syndrome		DOID:1056	OMIM:309000	J:185879

Genotype
MGI:5430752

cx2

• Allelic Composition: Inpp5b^tm1Nbm/Inpp5b^tm1Nbm; Ocrl^tm1Nbm/Y; Tg(INPP5B)CNbm/0
• Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

mortality/aging

premature death ( J:185879 )

♂ • a few mice die by 6 weeks of age

growth/size/body

decreased birth body size ( J:185879 )

♂ • in a few mice

decreased body weight ( J:185879 )

♂

postnatal growth retardation ( J:185879 )

♂ • by 4 weeks

renal/urinary system

aminoaciduria ( J:185879 )

♂

increased urine microglobulin level ( J:185879 )

♂

vision/eye

vision/eye phenotype ( J:185879 )

♂N • mice exhibit normal lens development and do not develop cataracts

homeostasis/metabolism

aminoaciduria ( J:185879 )

♂

increased urine microglobulin level ( J:185879 )

♂

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Dent disease		DOID:0050699	OMIM:300009 OMIM:300555	J:185879
oculocerebrorenal syndrome		DOID:1056	OMIM:309000	J:185879

Genotype
MGI:5430753

cx3

• Allelic Composition: Inpp5b^tm1Nbm/Inpp5b^tm1Nbm; Ocrl^tm1Nbm/Ocrl^tm1Nbm; Tg(INPP5B)CNbm/Tg(INPP5B)CNbm
• Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

growth/size/body

decreased body weight ( J:185879 )

♀

postnatal growth retardation ( J:185879 )

♀ • by 4 weeks

renal/urinary system

renal/urinary system phenotype ( J:185879 )

♀N • mice do not exhibit low molecular weight proteinuria

Genotype
MGI:5430754

cx4

• Allelic Composition: Inpp5b^tm1Nbm/Inpp5b^tm1Nbm; Ocrl^tm1Nbm/Y; Tg(INPP5B)CNbm/Tg(INPP5B)CNbm
• Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

growth/size/body

decreased body weight ( J:185879 )

♂

postnatal growth retardation ( J:185879 )

♂ • by 4 weeks

renal/urinary system

renal/urinary system phenotype ( J:185879 )

♂N • mice do not exhibit low molecular weight proteinuria