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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ephb6/Trpv6tm1.1Mfre
targeted mutation 1.1, Marc Freichel
MGI:5430771
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ephb6/Trpv6tm1.1Mfre/Ephb6/Trpv6tm1.1Mfre involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6N MGI:5430773


Genotype
MGI:5430773
hm1
Allelic
Composition		 Ephb6/Trpv6tm1.1Mfre/Ephb6/Trpv6tm1.1Mfre
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb6/Trpv6tm1.1Mfre mutation (0 available); any Ephb6 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
necrospermia ( J:185996 )
• reduced percentage of viable sperm in the cauda epididymis

reproductive system
reproductive system phenotype ( J:185996 )
N
• female mice exhibit normal fertility
• mice exhibit normal testis size and male germ cell meiosis
necrospermia ( J:185996 )
• reduced percentage of viable sperm in the cauda epididymis
abnormal epididymis epithelium morphology ( J:185996 )
• impaired calcium absorption with increased calcium in the epididymal fluid
impaired fertilization ( J:185996 )
• when using male sperm for in vitro fertilization
decreased fertilization frequency ( J:185996 )
• when using male sperm for in vitro fertilization

growth/size/body
growth/size/body region phenotype ( J:185996 )
N
• mice exhibit exhibit no growth defects




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory