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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grin1tm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:5431094
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Grin1tm1c(EUCOMM)Wtsi/Grin1tm2.1Stl
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Tg(Slc6a4-cre)ET127Gsat/0 		involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL MGI:5485189
cn2
 		Grin1tm1c(EUCOMM)Wtsi/Grin1tm2.1Stl
Tg(Slc6a4-cre)ET127Gsat/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL MGI:5485188
cn3
 		Grin1tm1c(EUCOMM)Wtsi/Grin1tm1c(EUCOMM)Wtsi
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Tg(Slc6a4-cre)ET127Gsat/0 		involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL MGI:5485191
cn4
 		Grin1tm1c(EUCOMM)Wtsi/Grin1tm1c(EUCOMM)Wtsi
Tg(Slc6a4-cre)ET127Gsat/0 		involves: C57BL/6 * C57BL/6N * FVB/N * SJL MGI:5485190


Genotype
MGI:5485189
cn1
Allelic
Composition		 Grin1tm1c(EUCOMM)Wtsi/Grin1tm2.1Stl
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Tg(Slc6a4-cre)ET127Gsat/0
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Cell Lines EPD0469_5_C11
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1c(EUCOMM)Wtsi mutation (1 available); any Grin1 mutation (68 available)
Grin1tm2.1Stl mutation (0 available); any Grin1 mutation (68 available)
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation (5 available); any Gt(ROSA)26Sor mutation (1006 available)
Tg(Slc6a4-cre)ET127Gsat mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal innervation ( J:193625 )
• disruption of somatic innervation during development in the absence of NMDARs at P14




Genotype
MGI:5485188
cn2
Allelic
Composition		 Grin1tm1c(EUCOMM)Wtsi/Grin1tm2.1Stl
Tg(Slc6a4-cre)ET127Gsat/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Cell Lines EPD0469_5_C11
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1c(EUCOMM)Wtsi mutation (1 available); any Grin1 mutation (68 available)
Grin1tm2.1Stl mutation (0 available); any Grin1 mutation (68 available)
Tg(Slc6a4-cre)ET127Gsat mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased excitatory postsynaptic current amplitude ( J:193625 )
• very small or no NMDAR excitatory postsynaptic currents at P10 and P13 to P14 in some ventral posteromedial nucleus neurons
• however, EPSCs from principal trigeminal nucleus are normal
abnormal NMDA-mediated synaptic currents ( J:193625 )
• at P13 to P14, deletion of NMDARs disrupts elimination of redundant inputs, synaptic strengthening and pruning of somatic innervation compared to in wild-type mice
• however, EPSCs from principal trigeminal nucleus are normal
reduced NMDA-mediated synaptic currents ( J:193625 )
• very small or no NMDAR excitatory postsynaptic currents at P10 and P13 to P14 in some ventral posteromedial nucleus neurons
abnormal miniature excitatory postsynaptic currents ( J:193625 )
• reduced frequency, amplitude and decay constant in the absence of NMDAR at P13




Genotype
MGI:5485191
cn3
Allelic
Composition		 Grin1tm1c(EUCOMM)Wtsi/Grin1tm1c(EUCOMM)Wtsi
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Tg(Slc6a4-cre)ET127Gsat/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Cell Lines EPD0469_5_C11
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1c(EUCOMM)Wtsi mutation (1 available); any Grin1 mutation (68 available)
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation (5 available); any Gt(ROSA)26Sor mutation (1006 available)
Tg(Slc6a4-cre)ET127Gsat mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal innervation ( J:193625 )
• disruption of somatic innervation during development in the absence of NMDARs at P14




Genotype
MGI:5485190
cn4
Allelic
Composition		 Grin1tm1c(EUCOMM)Wtsi/Grin1tm1c(EUCOMM)Wtsi
Tg(Slc6a4-cre)ET127Gsat/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * FVB/N * SJL
Cell Lines EPD0469_5_C11
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1c(EUCOMM)Wtsi mutation (1 available); any Grin1 mutation (68 available)
Tg(Slc6a4-cre)ET127Gsat mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased excitatory postsynaptic current amplitude ( J:193625 )
• very small or no NMDAR excitatory postsynaptic currents at P10 and P13 to P14 in some ventral posteromedial nucleus neurons
• however, EPSCs from principal trigeminal nucleus are normal
abnormal NMDA-mediated synaptic currents ( J:193625 )
• at P13 to P14, deletion of NMDARs disrupts elimination of redundant inputs, synaptic strengthening and pruning of somatic innervation compared to in wild-type mice
• however, EPSCs from principal trigeminal nucleus are normal
reduced NMDA-mediated synaptic currents ( J:193625 )
• very small or no NMDAR excitatory postsynaptic currents at P10 and P13 to P14 in some ventral posteromedial nucleus neurons
abnormal miniature excitatory postsynaptic currents ( J:193625 )
• reduced frequency, amplitude and decay constant in the absence of NMDAR at P13




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12/10/2024
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