Phenotypes associated with this allele

• Allele Symbol: Cacna1d^tm1Hgn
• Allele Name: targeted mutation 1, Hans Gerd Nothwang
• Allele ID: MGI:5431126
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cacna1d^tm1Hgn/Cacna1d^tm1Hgn Egr2^tm2(cre)Pch/Egr2^+	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:5431134

Genotype
MGI:5431134

cn1

• Allelic Composition: Cacna1d^tm1Hgn/Cacna1d^tm1Hgn; Egr2^tm2(cre)Pch/Egr2⁺
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal auditory brainstem response waveform shape ( J:185977 )

• above 60 dB, the amplitudes of waves II and III are increased compared to in control mice

• between 50 and 75 dB, wave I amplitude if slightly decreased compared to in control mice

• however, mice exhibit normal ABR thresholds for pure tone stimuli and in response to click or noise burst stimuli

abnormal distortion product otoacoustic emission ( J:185977 )

• slightly reduced at 50 dB SPL f2

increased or absent distortion product otoacoustic emission threshold ( J:185977 )

• slightly increased threshold in the middle hearing range

nervous system

abnormal pons morphology ( J:185977 )

• the lateral superior olive is round not U shape as in control mice and reduced in volume due to reduced neuron number

• the medial nucleus of the trapezoid body is reduced in volume due to reduced neuron number compared to in control mice

decreased neuron number ( J:185977 )

• in the lateral superior olive and medial nucleus of the trapezoid body