Analysis Tools
mortality/aging
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• fewer than expected are found
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reproductive system
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• loss of oocytes during prophase leaving only a few oocytes present at E18.5
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• depletion of all germinal cells in the seminiferous tubules
• depletion becomes more profound in older mice
• at 180 days of age, tubules are entirely empty
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• in spermatocytes
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• failure of meiotic progression
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• more than 60% of zygonema/pachynema cells show incomplete synapsis, synaptonemal complex (SC) fragments and SC gaps
• increased rate of SC interruptions
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• extensive oocyte apoptosis in early prophase
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• massive apoptosis of virtually all spermatocytes is seen following arrest
• cells that escape pachytene arrest enter apoptosis at later stages
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• mostly complete absence
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• mostly complete absence
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ovary cyst
(
J:185584
)
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• cysts lined with a layer of epithelial cells
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• decreased diameter
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• evident at 3 weeks of age
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• progressive atrophy starting before sexual maturity
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• absence of metaphase I/metaphase II cells, round spermatids, and spermatozoa
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azoospermia
(
J:185584
)
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• absent
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• reduced numbers
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• mostly arrest at stage IV of the epithelial cell cycle
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• failure of meiotic progression
• arrest in meiosis I
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homeostasis/metabolism
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• delayed in spermatocytes
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cellular
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• loss of oocytes during prophase leaving only a few oocytes present at E18.5
|
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• absent
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• reduced numbers
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• depletion of all germinal cells in the seminiferous tubules
• depletion becomes more profound in older mice
• at 180 days of age, tubules are entirely empty
|
azoospermia
(
J:185584
)
|
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• in spermatocytes
|
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• failure of meiotic progression
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• failure of meiotic progression
• arrest in meiosis I
|
|
• more than 60% of zygonema/pachynema cells show incomplete synapsis, synaptonemal complex (SC) fragments and SC gaps
• increased rate of SC interruptions
|
|
• extensive oocyte apoptosis in early prophase
|
|
|
• extensive oocyte apoptosis in early prophase
|
|
|
• massive apoptosis of virtually all spermatocytes is seen following arrest
• cells that escape pachytene arrest enter apoptosis at later stages
|
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• delayed in spermatocytes
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growth/size/body
ovary cyst
(
J:185584
)
|
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• cysts lined with a layer of epithelial cells
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• difference is more pronounced in males
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endocrine/exocrine glands
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• mostly complete absence
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• mostly complete absence
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ovary cyst
(
J:185584
)
|
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• cysts lined with a layer of epithelial cells
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• decreased diameter
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• evident at 3 weeks of age
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• progressive atrophy starting before sexual maturity
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