Phenotypes associated with this allele

• Allele Symbol: Rnaseh2b^tm1Hgu
• Allele Name: targeted mutation 1, MRC Human Genetics Unit
• Allele ID: MGI:5431529
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rnaseh2b^tm1Hgu/Rnaseh2b^tm1Hgu	involves: 129P2/OlaHsd * C57BL/6J	MGI:5431540

Genotype
MGI:5431540

hm1

• Allelic Composition: Rnaseh2b^tm1Hgu/Rnaseh2b^tm1Hgu
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality ( J:186180 )

• crosses between heterozygotes fail to produce offspring

embryo

caudal body truncation ( J:186180 )

embryonic growth retardation ( J:186180 )

• through gastrulation

decreased embryo size ( J:186180 )

• reduced embryo height and width at E7.5

• reduced in size through gastrulation

impaired somite development ( J:186180 )

• few or very small postcervical somites

abnormal allantois morphology ( J:186180 )

growth/size/body

embryonic growth retardation ( J:186180 )

• through gastrulation

decreased embryo size ( J:186180 )

• reduced embryo height and width at E7.5

• reduced in size through gastrulation

cellular

abnormal cell morphology ( J:186180 )

• by E11.5, mice exhibit increased numbers of cells with condensed or fragmented nuclei compared with wild-type mice