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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Droshatm1Ghan
targeted mutation 1, Gregory J Hannon
MGI:5431545
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Droshatm1Ghan/Droshatm1Ghan
Tg(KRT5-rtTA)1Glk/0
Tg(tetO-cre)1Jaw/0 		involves: 129 * C57BL/6 * FVB/N MGI:5431582


Genotype
MGI:5431582
cn1
Allelic
Composition		 Droshatm1Ghan/Droshatm1Ghan
Tg(KRT5-rtTA)1Glk/0
Tg(tetO-cre)1Jaw/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Droshatm1Ghan mutation (0 available); any Drosha mutation (96 available)
Tg(KRT5-rtTA)1Glk mutation (0 available)
Tg(tetO-cre)1Jaw mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal hair follicle bulge morphology ( J:183487 )
• at P50 doxycycline-treated mice exhibit loss of bulge stem cells unlike in control mice
• however, bulge stem cells are present at P20 and P22

growth/size/body
decreased body size ( J:183487 )
• in doxycycline-treated mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory