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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nuak2tm1Sia
targeted mutation 1, Shinichi Aizawa
MGI:5431630
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nuak2tm1Sia/Nuak2tm1Sia involves: C57BL/6NCrlj * CBA/JNCrlj MGI:5431632
cx2
Nuak1tm1Sia/Nuak1tm1Sia
Nuak2tm1Sia/Nuak2tm1Sia
involves: C57BL/6NCrlj * CBA/JNCrlj MGI:5431633


Genotype
MGI:5431632
hm1
Allelic
Composition
Nuak2tm1Sia/Nuak2tm1Sia
Genetic
Background
involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nuak2tm1Sia mutation (0 available); any Nuak2 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in 40% of embryos




Genotype
MGI:5431633
cx2
Allelic
Composition
Nuak1tm1Sia/Nuak1tm1Sia
Nuak2tm1Sia/Nuak2tm1Sia
Genetic
Background
involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nuak1tm1Sia mutation (1 available); any Nuak1 mutation (44 available)
Nuak2tm1Sia mutation (0 available); any Nuak2 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the median hinge point forms but the paired dorsolateral hinge points fail to form in the lower spine
• in the more caudal the neural plate is scarcely bent
• inefficient neural plate thickening
• failure of apical constriction after the 5 somite stage
• poor development of stable microtubules
• inefficient apical constriction and apico-basal elongation of neuroepithelial cells at the cranial layer
• in all embryos
• neither closure 2 nor 3 took place; however, closure 1 takes place and spreads caudally but not rostrally
• undulated in the closed section
• in all embryos

vision/eye
• overgrowth of the retinal pigment epithelium
• failure of optic fissure closure
• overgrowth of the neural retina

craniofacial
• in all embryos

growth/size/body
• in all embryos
• body wall defects similar to those in Nuak1tm1Sia single homozygotes

pigmentation
• overgrowth of the retinal pigment epithelium

embryo
• the median hinge point forms but the paired dorsolateral hinge points fail to form in the lower spine
• in the more caudal the neural plate is scarcely bent
• inefficient neural plate thickening
• failure of apical constriction after the 5 somite stage
• poor development of stable microtubules
• inefficient apical constriction and apico-basal elongation of neuroepithelial cells at the cranial layer
• in all embryos
• neither closure 2 nor 3 took place; however, closure 1 takes place and spreads caudally but not rostrally
• undulated in the closed section





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory