Allele Symbol Allele Name Allele ID |
Nuak2tm1Sia targeted mutation 1, Shinichi Aizawa MGI:5431630 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the median hinge point forms but the paired dorsolateral hinge points fail to form in the lower spine
• in the more caudal the neural plate is scarcely bent
• inefficient neural plate thickening
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• failure of apical constriction after the 5 somite stage
• poor development of stable microtubules
• inefficient apical constriction and apico-basal elongation of neuroepithelial cells at the cranial layer
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• in all embryos
• neither closure 2 nor 3 took place; however, closure 1 takes place and spreads caudally but not rostrally
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• undulated in the closed section
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• in all embryos
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• overgrowth of the retinal pigment epithelium
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• failure of optic fissure closure
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• overgrowth of the neural retina
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• in all embryos
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• in all embryos
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• body wall defects similar to those in Nuak1tm1Sia single homozygotes
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• overgrowth of the retinal pigment epithelium
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• the median hinge point forms but the paired dorsolateral hinge points fail to form in the lower spine
• in the more caudal the neural plate is scarcely bent
• inefficient neural plate thickening
|
• failure of apical constriction after the 5 somite stage
• poor development of stable microtubules
• inefficient apical constriction and apico-basal elongation of neuroepithelial cells at the cranial layer
|
• in all embryos
• neither closure 2 nor 3 took place; however, closure 1 takes place and spreads caudally but not rostrally
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• undulated in the closed section
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/22/2024 MGI 6.24 |
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