Phenotypes associated with this allele

• Allele Symbol: Trp53^tm1.1Wgu
• Allele Name: targeted mutation 1.1, Wei Gu
• Allele ID: MGI:5431727
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm1.1Wgu/Trp53^tm1.1Wgu	involves: 129S6/SvEvTac * C57BL/6	MGI:5431825

Genotype
MGI:5431825

hm1

• Allelic Composition: Trp53^tm1.1Wgu/Trp53^tm1.1Wgu
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:186159 )

N • mouse embryonic fibroblasts (MEFs) exhibit normal cell-cycle arrest and senescence

decreased cellular sensitivity to gamma-irradiation ( J:186159 )

• in thymocytes

• in the testes, intestines and spleen

decreased thymocyte apoptosis ( J:186159 )

• gamma-irradiation-induced apoptosis is virtually abrogated

increased fibroblast proliferation ( J:186159 )

• slightly in mouse embryonic fibroblasts

neoplasm

neoplasm ( J:186159 )

N • mice exhibit normal spontaneous tumors development

immune system

decreased thymocyte apoptosis ( J:186159 )

• gamma-irradiation-induced apoptosis is virtually abrogated

hematopoietic system

decreased thymocyte apoptosis ( J:186159 )

• gamma-irradiation-induced apoptosis is virtually abrogated

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:186159 )

• gamma-irradiation-induced apoptosis is virtually abrogated