Analysis Tools|
Allele Symbol Allele Name Allele ID |
Kcnq1ot1tm2.1Ckan targeted mutation 2.1, Chandrasekhar Kanduri MGI:5431827 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• loss of imprinting of ubiquitously imprinted genes when the Kcnq1ot1 allele is inherited paternally
• no alteration of imprinting status when the Kcnq1ot1 allele is inherited maternally
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• at 4 weeks of age when the Kcnq1ot1 allele is inherited maternally
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• loss of methylation in the somatic differentially methylated regions following tamoxifen treatment at E8.5 when the Kcnq1ot1 allele is inherited paternally
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• loss of imprinting of ubiquitously imprinted genes following tamoxifen treatment at E8.5 when the Kcnq1ot1 allele is inherited paternally
• however, silencing of placental-specific imprinted genes is variably maintained
• no alteration of imprinting status when the Kcnq1ot1 allele is inherited maternally
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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