Phenotypes associated with this allele

• Allele Symbol: Drd2^tm3.1Ebo
• Allele Name: targeted mutation 3.1, Emiliana Borrelli
• Allele ID: MGI:5431831
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Drd2^tm3.1Ebo/Drd2^tm3.1Ebo En1^tm2(cre)Wrst/En1^+	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:5431882
cn2	Drd2^tm3.1Ebo/Drd2^tm3.1Ebo Tg(Drd1a-cre)AGsc/0	involves: 129S2/SvPas * C57BL/6 * FVB/N	MGI:5431883

Genotype
MGI:5431882

cn1

• Allelic Composition: Drd2^tm3.1Ebo/Drd2^tm3.1Ebo; En1^tm2(cre)Wrst/En1⁺
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced behavioral response to xenobiotic ( J:185643 )

• mice fed cocaine exhibit increased locomotion compared with control mice

• mice exhibit enhanced response to nomifensine with greater relative contribution of dopamine transporter activity to peak amplitude compared with control mice

enhanced behavioral response to cocaine ( J:185643 )

• mice treated with cocaine exhibit increased hyperactivity compared with control mice

enhanced behavioral response to anesthetic ( J:185643 )

• mice exhibit increased catalepsy induced by haloperidol compared with control mice

hyperactivity ( J:185643 )

• in an open field

increased vertical activity ( J:185643 )

induced hyperactivity ( J:185643 )

• in mice fed cocaine

nervous system

abnormal nervous system electrophysiology ( J:185643 )

homeostasis/metabolism

abnormal dopamine level ( J:185643 )

• dopamine overflow evoked by a single stimulus in the dorsal striatum (DSt) is decreased compared to in control mice

• mice exhibit lower AMP evoked dopamine release compared with control mice

• dopamine reuptake is increased compared to in control mice

• mice exhibit enhanced response to nomifensine with greater relative contribution of dopamine transporter activity to peak amplitude compared with control mice

• following paired pulse, dopamine overflow is higher than in control mice

• single-pulse evoke dopamine overflow is decreased compared to in control mice

• multiple-pulse evoked dopamine overflow is increased compared to in wild-type mice

• however, quinpirole-treated mice exhibit normal dose-dependent inhibition of dopamine overflow

increased dopamine level ( J:185643 )

• in the nucleus accumbens (NAcc) and cortex

decreased physiological sensitivity to xenobiotic ( J:185643 )

• mice treated with quinpirole exhibit less of a decrease in locomotion compared with control mice

• mice treated with quinpirole in a novel environment fail to exhibit a decrease in locomotion compared with control mice

Genotype
MGI:5431883

cn2

• Allelic Composition: Drd2^tm3.1Ebo/Drd2^tm3.1Ebo; Tg(Drd1a-cre)AGsc/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

behavior/neurological

impaired behavioral response to cocaine ( J:185643 )

• mice treated with cocaine exhibit a blunted hyperactivity response compared with control mice

impaired behavioral response to anesthetic ( J:185643 )

• mice fail to exhibit catalepsy induced by haloperidol compared with control mice

impaired coordination ( J:185643 )

• on a rotarod

decreased locomotor activity ( J:185643 )

• in the home cage and open field

• in mice fed cocaine

nervous system

nervous system phenotype ( J:185643 )

N • mice exhibit normal dopamine levels

abnormal nervous system electrophysiology ( J:185643 )

• neurons exhibit smaller relative peak amplitudes compared with control neurons

homeostasis/metabolism

abnormal dopamine level ( J:185643 )

• dopamine overflow evoked by a single stimulus in the dorsal striatum (DSt) is decreased compared to in control mice

• quinpirole-treated mice exhibit attenuated inhibition of dopamine overflow compared with control mice

• mice exhibit lower AMP evoked dopamine release compared with control mice

• however, mice exhibit normal dopamine reuptake

decreased physiological sensitivity to xenobiotic ( J:185643 )

• mice fail to exhibit catalepsy induced by haloperidol compared with control mice

• mice treated with quinpirole exhibit less of a decreased in locomotion compared with control mice