Phenotypes associated with this allele

• Allele Symbol: Th^tm4.1Rpa
• Allele Name: targeted mutation 4.1, Richard D Palmiter
• Allele ID: MGI:5431878
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Th^tm4.1Rpa/Th^tm4.1Rpa Tg(Chx10-EGFP/cre,-ALPP)2Clc/0	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * SJL	MGI:5431886

Genotype
MGI:5431886

cn1

• Allelic Composition: Th^tm4.1Rpa/Th^tm4.1Rpa; Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
• Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal eye physiology ( J:185955 )

• about a 90% reduction in dopamine levels in the retina

• L-DOPA treatment rescues the visual defects

abnormal eye electrophysiology ( J:185955 )

• overall light-adapted b-wave amplitudes are reduced and the amplitude of the day/night rhythm is damped compared to controls in a light-adapted electroretinographic assay

• on day 2 in constant darkness, circadian regulation of the light-adapted electroretinographic response is abolished

abnormal vision ( J:185955 )

• optokinetic tracking indicates a decrease in contrast sensitivity

• visual acuity is reduced

homeostasis/metabolism

decreased dopamine level ( J:185955 )

• about a 90% reduction in the retina

• however, dopamine levels in the brain are preserved