Phenotypes associated with this allele

• Allele Symbol: Ar^tm2.1Reb
• Allele Name: targeted mutation 2.1, Robert E Braun
• Allele ID: MGI:5431884
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ar^tm2.1Reb/Ar^+ Tg(Amh-cre)8815Reb/?	129S(FVB)-Ar^tm2.1Reb	MGI:5571719

Genotype
MGI:5571719

cn1

• Allelic Composition: Ar^tm2.1Reb/Ar⁺; Tg(Amh-cre)8815Reb/?
• Genetic Background: 129S(FVB)-Ar^tm2.1Reb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal Sertoli cell barrier morphology ( J:210656 )

♂ • seminiferous tubules have stretches of severely disorganized Sertoli cell tight junctions interspersed with intact areas

♂ • preleptotene spermatocytes are enclosed in incomplete Sertoli cell tight junction compartments

abnormal Sertoli cell barrier function ( J:210656 )

♂ • serum albumin is detected in adluminal compartment of seminiferous tubules; an indication of Sertoli cell tight junction barrier dysfunction

reproductive system

abnormal Sertoli cell barrier morphology ( J:210656 )

♂ • seminiferous tubules have stretches of severely disorganized Sertoli cell tight junctions interspersed with intact areas

♂ • preleptotene spermatocytes are enclosed in incomplete Sertoli cell tight junction compartments

abnormal Sertoli cell barrier function ( J:210656 )

♂ • serum albumin is detected in adluminal compartment of seminiferous tubules; an indication of Sertoli cell tight junction barrier dysfunction