Phenotypes associated with this allele

• Allele Symbol: Sfrp2^tm1.1Brle
• Allele Name: targeted mutation 1.1, Brendan Lee
• Allele ID: MGI:5431901
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sfrp2^tm1.1Brle/Sfrp2^tm1.1Brle	B6;129-Sfrp2^tm1.1Brle/J	MGI:6509981
hm2	Sfrp2^tm1.1Brle/Sfrp2^tm1.1Brle	involves: 129S7/SvEvBrd	MGI:5431927
hm3	Sfrp2^tm1.1Brle/Sfrp2^tm1.1Brle	involves: 129S7/SvEvBrd * C57BL/6	MGI:5431926
cx4	Sfrp2^tm1.1Brle/Sfrp2^tm1.1Brle Sfrp4^tm1.1Boer/Sfrp4^tm1.1Boer	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * BALB/cJ	MGI:6509983

Genotype
MGI:6509981

hm1

• Allelic Composition: Sfrp2^tm1.1Brle/Sfrp2^tm1.1Brle
• Genetic Background: B6;129-Sfrp2^tm1.1Brle/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:275639 )

N • mice exhibit normal fertility

Genotype
MGI:5431927

hm2

• Allelic Composition: Sfrp2^tm1.1Brle/Sfrp2^tm1.1Brle
• Genetic Background: involves: 129S7/SvEvBrd

limbs/digits/tail

syndactyly ( J:186306 )

• Background Sensitivity: at 6 months, all mice exhibit a hind limb, unilateral, soft- tissue syndactyly between the third and fourth digit compared with some mice on a mixed background

Genotype
MGI:5431926

hm3

• Allelic Composition: Sfrp2^tm1.1Brle/Sfrp2^tm1.1Brle
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

skeleton

abnormal long bone diaphysis morphology ( J:186306 )

• calcified in distal limbs

decreased length of long bones ( J:186306 )

• mild mesomelic shortening

short radius ( J:186306 )

short ulna ( J:186306 )

short metacarpal bones ( J:186306 )

short metatarsal bones ( J:186306 )

delayed endochondral bone ossification ( J:186306 )

• ossification centers in the second phalanges are delayed compared to in wild-type mice

abnormal chondrocyte physiology ( J:186306 )

• decreased proliferation and delayed differentiation in distal limb skeletal elements at E17.5

• however, chondrocyte apoptosis rates are normal

limbs/digits/tail

brachypodia ( J:186306 )

brachydactyly ( J:186306 )

syndactyly ( J:186306 )

• at P1 and P4, mice exhibit syndactyly compared with wild-type mice

• Background Sensitivity: at 6 months, some mice exhibit a hind limb, unilateral, soft- tissue syndactyly between the third and fourth digit compared with all mice on a pure 129 background

short radius ( J:186306 )

short ulna ( J:186306 )

short metacarpal bones ( J:186306 )

short metatarsal bones ( J:186306 )

Genotype
MGI:6509983

cx4

• Allelic Composition: Sfrp2^tm1.1Brle/Sfrp2^tm1.1Brle; Sfrp4^tm1.1Boer/Sfrp4^tm1.1Boer
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * BALB/cJ

reproductive system

increased ovulation rate ( J:275639 )

♀ • increased ovulation

increased litter size ( J:275639 )

♀ • female mice exhibit increased litter size