All Phenotypes Sfrp2<tm1.1Brle> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sfrp2^tm1.1Brle
targeted mutation 1.1, Brendan Lee
MGI:5431901

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sfrp2^tm1.1Brle/Sfrp2^tm1.1Brle	B6;129-Sfrp2^tm1.1Brle/J	MGI:6509981
hm2	Sfrp2^tm1.1Brle/Sfrp2^tm1.1Brle	involves: 129S7/SvEvBrd	MGI:5431927
hm3	Sfrp2^tm1.1Brle/Sfrp2^tm1.1Brle	involves: 129S7/SvEvBrd * C57BL/6	MGI:5431926
cx4	Sfrp2^tm1.1Brle/Sfrp2^tm1.1Brle Sfrp4^tm1.1Boer/Sfrp4^tm1.1Boer	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * BALB/cJ	MGI:6509983

Allelic Composition	Sfrp2^tm1.1Brle/Sfrp2^tm1.1Brle
Genetic Background	B6;129-Sfrp2^tm1.1Brle/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp2^tm1.1Brle mutation (1 available); any Sfrp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:275639 )

N	• mice exhibit normal fertility

Allelic Composition	Sfrp2^tm1.1Brle/Sfrp2^tm1.1Brle
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp2^tm1.1Brle mutation (1 available); any Sfrp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:186306 )

• Background Sensitivity: at 6 months, all mice exhibit a hind limb, unilateral, soft- tissue syndactyly between the third and fourth digit compared with some mice on a mixed background

Allelic Composition	Sfrp2^tm1.1Brle/Sfrp2^tm1.1Brle
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp2^tm1.1Brle mutation (1 available); any Sfrp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal long bone diaphysis morphology ( J:186306 )

• calcified in distal limbs

decreased length of long bones ( J:186306 )

• mild mesomelic shortening

short radius ( J:186306 )

short ulna ( J:186306 )

short metacarpal bones ( J:186306 )

short metatarsal bones ( J:186306 )

delayed endochondral bone ossification ( J:186306 )

• ossification centers in the second phalanges are delayed compared to in wild-type mice

abnormal chondrocyte physiology ( J:186306 )

• decreased proliferation and delayed differentiation in distal limb skeletal elements at E17.5

• however, chondrocyte apoptosis rates are normal

limbs/digits/tail

brachypodia ( J:186306 )

brachydactyly ( J:186306 )

syndactyly ( J:186306 )

• at P1 and P4, mice exhibit syndactyly compared with wild-type mice

• Background Sensitivity: at 6 months, some mice exhibit a hind limb, unilateral, soft- tissue syndactyly between the third and fourth digit compared with all mice on a pure 129 background

short radius ( J:186306 )

short ulna ( J:186306 )

short metacarpal bones ( J:186306 )

short metatarsal bones ( J:186306 )

Allelic Composition	Sfrp2^tm1.1Brle/Sfrp2^tm1.1Brle Sfrp4^tm1.1Boer/Sfrp4^tm1.1Boer
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp2^tm1.1Brle mutation (1 available); any Sfrp2 mutation (30 available)
Sfrp4^tm1.1Boer mutation (0 available); any Sfrp4 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

increased ovulation rate ( J:275639 )

• increased ovulation

increased litter size ( J:275639 )

• female mice exhibit increased litter size

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24