Phenotypes associated with this allele

• Allele Symbol: Tg(Ly6e-MALT1)#Isg
• Allele Name: transgene insertion, Isidro Sanchez-Garcia
• Allele ID: MGI:5432016
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Trp53^tm1Tyj/Trp53^tm1Tyj Tg(Ly6e-MALT1)#Isg/0	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:5432018
tg2	Tg(Ly6e-MALT1)#Isg/0	involves: C57BL/6 * CBA	MGI:5432017

Genotype
MGI:5432018

cx1

• Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj; Tg(Ly6e-MALT1)#Isg/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Tg(Ly6e-MALT1)#Isg/0 Trp53^tm1Tyj/Trp53^tm1Tyj mice develop activated B-cell diffuse large-cell lymphoma

mortality/aging

premature death ( J:185590 )

• die earlier than transgenic mice wild-type for Trp53

neoplasm

increased B cell derived lymphoma incidence ( J:185590 )

• develop aggressive lymphomas characterized by a diffuse infiltrate of large B-lymphocytes with nuclei with dispersed chromatin, deeply basophilic cytoplasm and multiple mitotic figures

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
diffuse large B-cell lymphoma		DOID:0050745		J:185590

Genotype
MGI:5432017

tg2

• Allelic Composition: Tg(Ly6e-MALT1)#Isg/0
• Genetic Background: involves: C57BL/6 * CBA

Tg(Ly6e-MALT1)#Isg/0 mice develop extranodal mucosa-associated lymphoid tissue lymphomas

mortality/aging

premature death ( J:185590 )

neoplasm

increased B cell derived lymphoma incidence ( J:185590 )

• develop human like MALT lymphomas

• tumors involve different extranodal sites including the small intestine, salivary glands, kidneys, lungs, liver, stomach, ocular adnexa, and spleen, but do not affect the lymph nodes

• many mice (17 of 26) have tumors involving more than 1 site

• tumors are comprised of a morphologically heterogeneous lymphoid population, predominantly composed of marginal zone (centrocyte-like) cells mixed with small lymphocytes, scattered large blasts, and plasma cells

immune system

increased pro-B cell number ( J:185590 )

• in the bone marrow

increased mature B cell number ( J:185590 )

• moderate accumulation in the peripheral blood and spleen but not in the lymph nodes

increased pre-B cell number ( J:185590 )

• in the bone marrow

hematopoietic system

increased pro-B cell number ( J:185590 )

• in the bone marrow

increased mature B cell number ( J:185590 )

• moderate accumulation in the peripheral blood and spleen but not in the lymph nodes

increased pre-B cell number ( J:185590 )

• in the bone marrow

increased hematopoietic stem cell number ( J:185590 )

• expansion of Sca1+ Kit+ Lin- cells in the bone marrow

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue		DOID:0050909	OMIM:137245	J:185590