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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm2.1Kasa
targeted mutation 2.1, Kanaga Sabapathy
MGI:5432141
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp53tm2.1Kasa/Trp53tm2.1Kasa involves: 129P2/OlaHsd * C57BL/6 MGI:5432144
cx2
 		Mdm2tm1Bay/Mdm2tm1Bay
Trp53tm2.1Kasa/Trp53tm2.1Kasa 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:5432145


Genotype
MGI:5432144
hm1
Allelic
Composition		 Trp53tm2.1Kasa/Trp53tm2.1Kasa
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm2.1Kasa mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:186335 )
N
• viable

reproductive system

neoplasm
neoplasm ( J:186335 )
N
• mice exhibit normal spontaneous and induced tumorigenesis

cellular
cellular phenotype ( J:186335 )
N
• mouse embryonic fibroblasts exhibit normal sensitivity to gamma-radiation and proliferation




Genotype
MGI:5432145
cx2
Allelic
Composition		 Mdm2tm1Bay/Mdm2tm1Bay
Trp53tm2.1Kasa/Trp53tm2.1Kasa
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Bay mutation (1 available); any Mdm2 mutation (54 available)
Trp53tm2.1Kasa mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory