Phenotypes associated with this allele

• Allele Symbol: Nxnl1^tm1.2Tlev
• Allele Name: targeted mutation 1.2, Thierry Leveillard
• Allele ID: MGI:5432155
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nxnl1^tm1.2Tlev/Nxnl1^tm1.2Tlev	involves: BALB/c * BALB/cJ * C57BL/6	MGI:5432158

Genotype
MGI:5432158

hm1

• Allelic Composition: Nxnl1^tm1.2Tlev/Nxnl1^tm1.2Tlev
• Genetic Background: involves: BALB/c * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

decreased retina cone cell number ( J:186370 )

thin retina outer nuclear layer ( J:186370 )

abnormal eye physiology ( J:186370 )

• cone function is vulnerable to hyperoxia-induced damage unlike in wild-type mice

abnormal cone electrophysiology ( J:186370 )

• at 7 and 12 months, mice exhibit reduced cone b-wave amplitude compared with wild-type mice

• however, b-wave amplitude is normal at 3 months

abnormal rod electrophysiology ( J:186370 )

• at 3, 7 and 12 months, mice exhibit a reduction in a- and b-waves compared with wild-type mice

abnormal vision ( J:186370 )

homeostasis/metabolism

abnormal lipid homeostasis ( J:186370 )

• at 18 months, lipid peroxidation in the retina and cones is sensitive to hyperoxia compared to in wild-type mice

nervous system

microgliosis ( J:186370 )

decreased retina cone cell number ( J:186370 )

immune system

microgliosis ( J:186370 )

hematopoietic system

microgliosis ( J:186370 )